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Abstract

Validated HPTLC Method For Estimation Of Lamotrigine In Tablets

Author(s): K. M Patil, A. K Aggarwal, S. L Bodhankar

A simple, specific and precise high performance thin-layer chromatography method has been developed for estimation of lamotrigine in its tablet dosage form. In this method, standard solution and sample solution of lamotrigine were applied on precoated silica gel G60 F254 TLC plate and developed using a mixture of acetone: toluene: ammonia (70:30:5.0 v/v) as mobile phase. The quantification was done by densitometry at 312 nm. The method was quantitatively evaluated in terms of linearity, accuracy, precision, repeatability and specificity to prove its utility in the analysis of tablet dosage form.