Visible Spectrophotometric Methods For Estimation Of Amlodipine Besylate Form Tablets
Three simple, sensitive and accurate extractive colorimetric methods for estimation of Amlodipine besylate from tablet formulation have been developed. The developed methods involve formation of coloured chloroform extractable ion pair complexes of the drug with bromocresol green (BCG), bromophenol blue (BPB) and methylene blue (MB) in acidic medium. Extracted complexes showed absorbance maxima at 409.0 nm (BCG), 409.0 nm (BPB) and 668.2 nm (MB). Beer's law is obeyed in the concentration range employed (0-80 mcg/ml) for all the three methods. Results of analysis were validated statistically and through recovery studies.