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Abstract

Visible Spectrophotometric Methods For The Determination Of Nateglinide In Tablets Through Schiff's Base Formation

Author(s): G Vidya Sagar, N. V. S Gangadhara Rao, B. S Sastry

Two simple spectrophotometric methods for the analysis of nateglinide in pure form or pharmaceutical formulations have been developed based on the reaction of the drug with aromatic aldehydes, vanillin and paradimethyl amino cinnamaldehyde in acidic medium producing coloured Schiff's bases having λmax at 580 nm and 420 nm, respectively. Good agreement with Beer's law was found in the range of 25-150 μg/ml for method A and 20-140 μg/ml for method B. The methods are simple, precise and accurate with excellent recovery of 98-102% and also do not require any separation of soluble excipients in pharmaceutical preparations. The results obtained are reproducible with coefficient of variation of less than 1.0%.