All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Visible spectrophotometric methods for the estimation of metoclopramide hydrochloride in tablets

Author(s): SA Patel, CN Patel, MM Patel
Shree S. K. Patel College of Pharmaceutical Education and Research, Ganpat Vidyanagar, Kherva-382 711, India

Correspondence Address:
S A Patel Shree S. K. Patel College of Pharmaceutical Education and Research, Ganpat Vidyanagar, Kherva-382 711 India E-mail: [email protected]


Two simple, sensitive, accurate, and rapid visible spectrophotometric methods have been developed for the estimation of metoclopramide hydrochloride in tablets. Method A is based on the reaction of drug with 4-dimethyl amino-benzaldehyde (Ehrlich reagent) to yield a yellow colour Schiff's base, which shows maximum absorbance at 438 nm against reagent blank, while method B is based on diazotisation of primary amine group of metoclopramide hydrochloride with sodium nitrite and hydrochloric acid followed by coupling with β-napthol (in alkaline medium) to form a red colour dye, which shows maximum absorbance at 553 nm against reagent blank. Beer's law was obeyed in the concentration range of 10-100 µg/ml in method A and 1-10 µg/ml in method B. Results of the analysis were validated statistically and by recovery studies.



Share this