Wound healing activity of Leucas hirta
1 Department of Botany, S. R. N. M. N. College of Applied Sciences, Shimoga-577 201, India 2 Department of Biotechnology, S. R. N. M. N. College of Applied Sciences, Shimoga-577 201, India 3 Department of Biotechnology, Kuvempu University, Shankaraghatta-577 451, India 4 Department of Pharmacology, National College of Pharmacy, Shimoga-577 201, India
B K Manjunatha Department of Botany, S. R. N. M. N. College of Applied Sciences, Shimoga-577 201 India E-mail: [email protected]
The wound healing efficacy of aqueous and methanolic leaf extracts of Leucas hirta was evaluated in excision, incision and dead space wound models. The parameters studied include rate of wound contraction, period of complete epithelialization, tensile strength of incision wound and granulation tissue, granulation tissue dry weight, hydroxyproline content and histological studies of granulation tissue. Among the two extracts studied, methanol leaf extract was found to possess significant wound healing activity followed by aqueous extract, which was evidenced by decrease in the period of epithelialization, increase in the rate of wound contraction, skin breaking strength, granulation tissue dry weight, hydroxyproline content and breaking strength of granulation tissue. Histopathological study of the granulation tissue evidenced increased collagenation when compared to control group of animals.