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| Year : 1988 | Volume
: 50
| Issue : 1 | Page : 40-42 |
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Kinetics of bacteriostatic activity of chloroquine on staphylococcus aureus.
YB Acheampong
Dept. of Pharmaceutical Microbiology & Clinical Pharmacy, University of Ibadan, Nigeria,
Correspondence Address:
Y B Acheampong
Dept. of Pharmaceutical Microbiology & Clinical Pharmacy, University of Ibadan, Nigeria
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Microbial kinetics have been employed to study the mechanism of antibacterial activity of chloroquine on S. aureus. Cultures treated with the drug in growth medium showed biphasic steady-state generation curves, the apparent rate constant for the phase I was smaller than for phase II. The bacteriostatic activity of the drug was associated with the first phase of drug-bacteria reaction, which was also affected by changes in pH of the growth medium. |
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