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| Year : 1993 | Volume
: 55
| Issue : 4 | Page : 159-161 |
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Preformulation studies of a prodrug of ciprofloxacin.
AG Swaminathan, SP Agarwal
Dept. of Pharmaceutics, Faculty of Pharmacy Jamia Hamdard, New Delhi-110 062,
Correspondence Address:
A G Swaminathan
Dept. of Pharmaceutics, Faculty of Pharmacy Jamia Hamdard, New Delhi-110 062
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A prodrug of Ciprofloxacin was synthesized by reacting the free base with aqueous formaldehyde solution in a 1:1 mixture of methylene chloride and methanol. The colourless, crystalline Nhydroxymethyl derivative, m.p. 238-242 degree C showed enhanced solubility and a three fold increase in the dissolution rate over parent drug. The degradation kinetics, pH-rate profile and antimicrobial activity of the prodrug were also determined. |
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