|
|
| Year : 1998 | Volume
: 60
| Issue : 1 | Page : 41-44 |
|
|
Formulation And In Vitro Evaluation Of Centchroman - Loaded Biodegradable Microspheres
B. D Shenoy, D Kini, N Udupa
,
Correspondence Address:
B. D Shenoy
|
|
|
Centchroman, a non-steroidal contraceptive was formulated as biodegradable microspheres using alginate, chitosan, albumin and poly (lactic-co-glycolic) acid polymers. They were evaluated for physicochemical characteristics, in vitro release profile in phosphate buffered saline (pH 7.4) and stability on storage at different conditions. All the formulations exhibited a prolonged drug release with significant (P<0.05) increase in stability at specified conditions of storage. It was observed that PLGA microsphere was the best biodegradable carrier for Centchroman amongst the others studied. |
|
|
|
| [PDF]* |
|
 |
|
