Indian Journal of Pharmaceutical Sciences
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Scientific Publication of the Indian Pharmaceutical Association
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Year : 1999  |  Volume : 61  |  Issue : 6  |  Page : 342-345

Guar Gum As A Hydrophilic Matrix For Preparation Of Theophylline Controlled - Release Dosage Form


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P Khullar

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Compressed tablets were prepared from theophylline and guar gum. Effect of the viscosity grade of the polymer and polymer content in the tablets on release pattern of theophylline was examined in vitro. Release rate was retarded with increase in polymer content as well as the viscosity grade of polymer. Dissolution profile was independent of pH, while the compression pressure had only marginal effect on release pattern. In vivo crossover study with twelve human volunteers following oral 'administration, shown that guar gum formulation of theophylline is bioequivalent with the marketed product Theodur.

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