Indian Journal of Pharmaceutical Sciences
Users online: 25
Scientific Publication of the Indian Pharmaceutical Association
Home Email this page Print this page Bookmark this page Decrease font size Default font size Increase font size
The Journal Search Current Issue Archives Instructions Online submission Login  
Year : 1999  |  Volume : 61  |  Issue : 6  |  Page : 350-357

Sensitive HPLC Method For Biovailability And Bioequivalence Studies Of Theophylline SR Formulations


,

Correspondence Address:
C. J Shishoo


Login to access the Email id


Get Permissions

As part of ongoing programme on the development of a sustained release (SR) formulation of theophylline (200 mg capsule) and determination of its bioavailability, a specific, sensitive and simple HPLC method has been developed for the estimation of lower mg levels of theophylline in plasma. 8-Chlorotheophylline was used as an internal standard. With simple extraction of theophylline from plasma, the method has a, linearity range of 0.5 to 30 mg/ml and an average recovery of 79.32% for theophylline and 88.49% for the internal standard, respectively. Theophylline plasma concentration versus time data is presented for the test formulation (T) (SR capsule, 200 mg) and a standard formulation (S) (SR tablet, 200 mg). Different pharmacokinetic parameters for formulation T and formulation S were estimated and compared statistically for determination of their bioequivalence.


[PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed266    
    Printed12    
    Emailed0    
    PDF Downloaded43    
    Comments [Add]    

Recommend this journal