Indian Journal of Pharmaceutical Sciences
Users online: 50
Scientific Publication of the Indian Pharmaceutical Association
Home Email this page Print this page Bookmark this page Decrease font size Default font size Increase font size
The Journal Search Current Issue Archives Instructions Online submission Login  
Year : 1999  |  Volume : 61  |  Issue : 6  |  Page : 362-365

Single Dose Bioequivalence Study Of Two Brands Of Chloroquine Phosphate Tablets Using Salivary Kinetics


,

Correspondence Address:
C Jayanathi


Login to access the Email id


Get Permissions

The present study was undertaken to evaluate the feasibility of salivary kinetics of chloroquine as an approach to biopharmaceutical and pharmacokinetic assessment and to test the bioequivalency of two marketed brands of chloroquine phosphate tablets using noninvasive saliva sampling technique. Pharmacokinetic parameters were computed following oral administration of a single dose of 600 mg of chloroquine base (250 mgx4 chloroquine phosphate tablets) to ten human healthy volunteers. All volunteers received medication in a two period, two way cross-over design. The difference between the formulations were statistically insignificant. In all the cases the relative bioavailability of the test formulation, B was found to be in the range of 84-115%. No adverse reactions were observed during the entire study except for mild dizziness in 70% of the volunteers.


[PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed200    
    Printed15    
    Emailed0    
    PDF Downloaded13    
    Comments [Add]    

Recommend this journal