Indian Journal of Pharmaceutical Sciences
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Scientific Publication of the Indian Pharmaceutical Association
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Year : 1999  |  Volume : 61  |  Issue : 6  |  Page : 385-388

Synthesis Of 1-(2’-Hyroxybenzoyl)-5-(Substituted Phenyl)-3-(2’-Methylindolyl)-2-Pyrazolines As Anti Inflammatory Agents


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Ekta Bansal


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1-(2'-hydroxybenzoyl)-5-(substituted phenyl)-3-(2'-methylindolyl)-2-Pyrazolines were prepared by the cyclocondensation of 2-methyl-3-indolyl substituted chalcones with salicylic acid hydrazide through Michael condensation, which in turn were synthesized by the reaction of 3-acetyl-2-methylindole and substituted aromatic aldehydes. These compounds were screened for antiinflammatory activity, ulcerogenic potential, CVS activity and acute toxicity. Compound 1-(2'-hydroxybenzoyl)-5-(2'-fluorophenyl)- 3-(2'-methylindolyl)-2-pyrazoline showed the most potent antiinflammatory activity.


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