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| Year : 2003 | Volume
: 65
| Issue : 4 | Page : 407-409 |
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Simultaneous Reverse Phase HPLC Estimation Of Nimesulide And Diclofenac Sodium
K.E.V Nagoji, S Vijayasrinivas, M Kiran Kumar, N Mathivanan, M Satish Kumar, M.E.B Rao
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Correspondence Address:
K.E.V Nagoji
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A simple, selective, rapid, precise and economical reverse phase HPLC method has been developed for the simultaneous estimation of nimesulide and diclofenac sodium from capsules. The analyte was resolved by using a mobile phase (methanol and water in the ratio 50:50) at a flow rate of 1 ml/min. on an isocratic HPLC system consisting of LC-10 AT liquid pump, SPD-1OA UV/Visible detector, a ODs C-18 RP column (4.6 mm I.D. x 25 cm) at a wavelength of 230 nm. The linear dynamic range for both nimesulide and diclofenac sodium was 0.5-30 μg/ml and 2.0-30 μg/ ml respectively by this method. Paracetamol was used as an internal standard. |
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