|
|
| Year : 2003 | Volume
: 65
| Issue : 4 | Page : 432-435 |
|
|
Spectrophotometric Determination Of Promethazine Hydrochloride In Pharmaceutical Formulations
K.C Ramesh, B.G Gowda, J Keshavayya
,
Correspondence Address:
K.C Ramesh
|
|
|
A simple, rapid and selective spectrophotometric method has been proposed for the assay of promethazine hydrochloride in pure and pharmaceutical formulations. The method is based on the formation of a chloroform-soluble red coloured product having an absorption maximum at 516 nm with o-toluidine in presence of N-bromosuccinimide. The reaction conditions were optimized. Beer's law is valid in the concentration range 2-15 μg/ml (r=0.9993) having molar absorptivity of 4.64X103 I/mol.cm. The results obtained by the proposed method were compared by means of Student t- test and by the F-test with those of official method and were found to be in good agreement. No interference was observed from common excipients. Moreover, the method is specific for C-2 unsubstituted phenothiazines. |
|
|
|
| [PDF]* |
|
 |
|
