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| Year : 2004 | Volume
: 66
| Issue : 1 | Page : 82-86 |
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Synthesis And Antimicrobial Activity Of Some Novel 6-Bromo-2-Methyl/phenyl-3-(Sulphonamido) quinazolin-4(3H)- Ones
P Selvam, K Vanitha, M Chandramohan, E De Clercq
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Correspondence Address:
P Selvam
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A series of novel 2-substituted-3-(sulphonamido) quinazolin-4 (3H)-ones have been synthesized by condensing the primary amino group of sulphamoxole and sulphadimidine with 2-substituted benzoxazin-2-one. The compounds synthesized were screened for antibacterial activity
(Escherichia coli and Staphylococcus aureus) antiviral activity (Herpes simplex virus type 1 and 2 in E6SM cells, HIV-1 and 2 in MT-4 cells), all the test compounds exhibited comparable antibacterial activity with that of standards sulphamoxole and sulphadimidine. |
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