Indian Journal of Pharmaceutical Sciences
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Scientific Publication of the Indian Pharmaceutical Association
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Year : 2005  |  Volume : 67  |  Issue : 6  |  Page : 725-731

Synthesis And Pharmacological Evaluation Of Some Potent 2-(4-Substitutedphenyl)-4,5-Diphenyl-1H-Imidazoles.


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A Puratchikody


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The reaction between benzil and ammonium acetate with appropriate aldehyde(s) in glacial acetic acid readily gives 2-(4-substitutedphenyl)- 4,5-diphenyl-1H-imidazole (1-10). The spectra (IR, 1H and 13C NMR and MS) and analytical data have supported their structures. Toxicity of 1-10 has been determined. Analgesic, antiinflammatoy, antiepileptic and locomotor activities of the compounds 1-10 have been evaluated by standard methods.


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