Indian Journal of Pharmaceutical Sciences
Users online: 30
Scientific Publication of the Indian Pharmaceutical Association
Home Email this page Print this page Bookmark this page Decrease font size Default font size Increase font size
The Journal Search Current Issue Archives Instructions Online submission Login  
RESEARCH PAPER
Year : 2006  |  Volume : 68  |  Issue : 5  |  Page : 570-574

Tumour response to quercetin, a bioflavonoid with some promises in therapies


1 Chemotherapy, Cancer Research Institute, Tata Memorial Centre, ACTREC, Kharghar, Navi Mumbai-410 208, India
2 Animal House, Cancer Research Institute, Tata Memorial Centre, ACTREC, Kharghar, Navi Mumbai-410 208, India

Correspondence Address:
A D Ingle
Animal House, Cancer Research Institute, Tata Memorial Centre, ACTREC, Kharghar, Navi Mumbai-410 208
India
Login to access the Email id


DOI: 10.4103/0250-474X.29621

Get Permissions

Quercetin, a well-known bioflavonoid, is commonly found in human diet. This flavonoid along with Genistein gained much attention during the last few years as a potential anticancer drug. The purpose of this study was to investigate the effect of quercetin on tumour growth in vivo after determining its toxicological profile. The maximum tolerated dose (MTD) of quercetin was found to be 100 mg/kg. Fifty percent of the S-180 ascitic tumour bearing mice, treated with quercetin with a daily intraperitoneal dose (100 mg/kg) for nine consecutive doses, survived for more than 2 mo. Quercetin did not show significant inhibitory effect on the growth of established mammary tumour inoculated in C3H/J mice. However, increase in tumour size was significantly lower when administered in combination with cyclophosphamide compared to remaining groups. Quercetin was found to be protecting the mouse bone marrow from radiation-induced toxicity by creating hypoxic conditions in the marrow. Hypoxic conditions resulted in elevated LDH levels in quercetin-treated group compared to levels in the control group. Haematological parameters did not show significant difference in treated and control groups. Spleen colony assays suggest quercetin to be nontoxic and that it can be administered at 100 mg/kg dose levels in further studies.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed7786    
    Printed123    
    Emailed7    
    PDF Downloaded306    
    Comments [Add]    
    Cited by others 3    

Recommend this journal