Indian Journal of Pharmaceutical Sciences
Users online: 42
Scientific Publication of the Indian Pharmaceutical Association
Home Email this page Print this page Bookmark this page Decrease font size Default font size Increase font size
The Journal Search Current Issue Archives Instructions Online submission Login  
RESEARCH PAPER
Year : 2006  |  Volume : 68  |  Issue : 5  |  Page : 626-630

In vitro microbiological evaluation of polyvinyl alcohol-based ocular inserts of Ciprofloxacin hydrochloride


1 Department of Pharmaceutics, Institute of Technology, Banaras Hindu University, Varanasi-221 005, India
2 Department of Microbiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi-221 005, India

Correspondence Address:
J K Pandit
Department of Pharmaceutics, Institute of Technology, Banaras Hindu University, Varanasi-221 005
India
Login to access the Email id


DOI: 10.4103/0250-474X.29631

Get Permissions

Soluble inserts of ciprofloxacin hydrochloride using high and low molecular weight polyvinyl alcohol alone and in various combinations were fabricated by a casting technique. The in vitro drug release from the prepared inserts was studied using a continuous flow-through model, developed in our laboratory. The antimicrobial efficacies of the prepared inserts against common ocular pathogens, viz., Staphylococcus aureus ATCC 25923 and Pseudomonas aeruginosa ATCC 27853, were evaluated using a modified in vitro microbiological model. Ciprofloxacin hydrochloride release from the inserts followed matrix diffusion kinetics showing an anomalous release mechanism (erosion-controlled) based on the calculated release exponent (n) values. Drug release increased with an increase in the proportion of high molecular weight polyvinyl alcohol in the inserts. The in vitro microbiological model demonstrated the effectiveness of the inserts against the two microorganisms. Further, the results of the in vitro release studies correlated well with that of the antimicrobial studies.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed9378    
    Printed79    
    Emailed9    
    PDF Downloaded374    
    Comments [Add]    
    Cited by others 6    

Recommend this journal