Indian Journal of Pharmaceutical Sciences
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Scientific Publication of the Indian Pharmaceutical Association
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Year : 2006  |  Volume : 68  |  Issue : 5  |  Page : 639-640

UV spectrophotometric simultaneous estimation of valdecoxib and paracetamol in combined tablet dosage form


J. L. Chaturvedi College of Pharmacy, New Nandanvan, Nagpur-440 009, India

Correspondence Address:
Vaishali Nagulwar
J. L. Chaturvedi College of Pharmacy, New Nandanvan, Nagpur-440 009
India
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DOI: 10.4103/0250-474X.29634

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The present work deals with the development of a simple, accurate and economical method for the simultaneous estimation of valdecoxib and paracetamol in combined tablet dosage form by Vierodt's UV spectrophotometric method. The λmax values of valdecoxib and paracetamol in 0.1 N NaOH were 244 nm and 257 nm respectively. Both the drugs followed Beer's law in the concentration range of 1-6 g/ml and 5-30 g/ml respectively. The A1% 1 cm values for valdecoxib and paracetamol at 244 nm and 257 nm were 520 and 420, 510.8 and 636.8 respectively.


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