Indian Journal of Pharmaceutical Sciences
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Scientific Publication of the Indian Pharmaceutical Association
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Year : 2006  |  Volume : 68  |  Issue : 5  |  Page : 643-645

Spectrophotometric analysis of fosinopril sodium in pure form and tablets


Pharmacy Department, Faculty of Technology and Engineering, The M. S. University of Baroda, Kalabhavan, Vadodara-390 001, India

Correspondence Address:
Rajashree Mashru
Pharmacy Department, Faculty of Technology and Engineering, The M. S. University of Baroda, Kalabhavan, Vadodara-390 001
India
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DOI: 10.4103/0250-474X.29636

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Simple UV and third derivative spectrophotometric methods in methanol have been developed for the determination of fosinopril sodium in bulk drug and its pharmaceutical formulations. The simple UV spectrum of fosinopril sodium in methanol exhibits absorption maxima (λmax) at 208 nm, whereas in the third derivative spectrum the maxima occur at 217.4 nm and the minima at 223 nm. Both the methods were found to be simple, economical, accurate, reproducible and can be adopted in routine analysis of fosinopril sodium in bulk drug and in tablet dosage form.


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