Indian Journal of Pharmaceutical Sciences
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Scientific Publication of the Indian Pharmaceutical Association
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Year : 2006  |  Volume : 68  |  Issue : 5  |  Page : 656-657

Visible spectrophotometric methods for estimation of repaglinide in tablet formulation


1 B. N. P. G. College of Pharmacy, Udaipur-313 002, India
2 Department of Pharmaceutical Sciences, M. L. Sukhadia University, Udaipur-313 001, India

Correspondence Address:
I Singhvi
Department of Pharmaceutical Sciences, M. L. Sukhadia University, Udaipur-313 001
India
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DOI: 10.4103/0250-474X.29641

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Two simple, economical, precise and reproducible visible spectrophotometric methods have been developed for the estimation of repaglinide in tablet formulation. The developed methods are based on the formation of chloroform extractable complex of repaglinide with zincon and methylthymol blue in acidic medium. The extracted complex with zincon shows absorbance maxima at 533.0 nm and linearity in the concentration range of 50-250 g/ml. The extracted complex with methylthymol blue shows absorbance maxima at 427.0 nm and linearity in the concentration range of 100-500 g/ml. Results of analysis for both the methods were validated statistically and by recovery studies.


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