Indian Journal of Pharmaceutical Sciences
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Scientific Publication of the Indian Pharmaceutical Association
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Year : 2006  |  Volume : 68  |  Issue : 5  |  Page : 658-659

UV-spectrophotometric estimation of ranitidine and domperidone in tablet formulations


Department of Pharmaceutical Sciences, Rashtrasant Tukdoji Maharaj Nagpur University Campus, Amrawati Road, Nagpur-440 033, India

Correspondence Address:
M S Charde
Department of Pharmaceutical Sciences, Rashtrasant Tukdoji Maharaj Nagpur University Campus, Amrawati Road, Nagpur-440 033
India
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DOI: 10.4103/0250-474X.29642

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A simple, fast, precise multicomponent mode analysis method has been developed for simultaneous estimation of ranitidine and domperidone in tablet formulation. The sampling wavelengths selected for both the drugs were 229 nm, 245 nm, 270 nm, 285 nm, 294 nm on trial-and-error basis using methanol as solvent. The linearity for both the drugs at all the selected wavelengths lies between 3.0 and 50 g/ml for ranitidine and 0.2 and 3.5 g/ml for domperidone. The concentrations of both the drugs were evaluated in laboratory mixture and marketed formulation. The recovery study was carried out by standard addition method.


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