Indian Journal of Pharmaceutical Sciences
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Scientific Publication of the Indian Pharmaceutical Association
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Year : 2006  |  Volume : 68  |  Issue : 5  |  Page : 675-677

RP-HPLC estimation of paracetamol and valdecoxib in combined dosage form


1 Department of Pharmaceutical Chemistry, R. C. Patel College of Pharmacy, Shirpur-425 405, India
2 JZMDS College of Pharmacy, Mamurabad, Jalgaon-425 001, India

Correspondence Address:
G S Talele
JZMDS College of Pharmacy, Mamurabad, Jalgaon-425 001
India
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DOI: 10.4103/0250-474X.29649

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A reverse phase high performance liquid chromatography method was developed for simultaneous estimation of paracetamol and valdecoxib in tablet formulation. The separation was achieved by Luna C 18 column and methanol: phosphate buffer pH 3.5 (60:40 v/v) as eluent, at a flow rate of 1.0 ml/min. Detection was carried out at 242 nm. Etoricoxib was used as an internal standard. The retention time of PAR and VAL was found to be 3.01 and 8.51 min, respectively. The method was validated for linearity, accuracy and precision. Linearity for paracetamol and valdecoxib were in the range 25-150 g/ml and 1-6 g/ml, respectively. The developed method was found to be accurate, precise, and selective for simultaneous estimation of paracetamol and valdecoxib in tablets.


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