Indian Journal of Pharmaceutical Sciences
Users online: 443
Scientific Publication of the Indian Pharmaceutical Association
Home Email this page Print this page Bookmark this page Decrease font size Default font size Increase font size
The Journal Search Current Issue Archives Instructions Online submission Login  
Year : 2006  |  Volume : 68  |  Issue : 5  |  Page : 675-677

RP-HPLC estimation of paracetamol and valdecoxib in combined dosage form

1 Department of Pharmaceutical Chemistry, R. C. Patel College of Pharmacy, Shirpur-425 405, India
2 JZMDS College of Pharmacy, Mamurabad, Jalgaon-425 001, India

Correspondence Address:
G S Talele
JZMDS College of Pharmacy, Mamurabad, Jalgaon-425 001
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0250-474X.29649

Get Permissions

A reverse phase high performance liquid chromatography method was developed for simultaneous estimation of paracetamol and valdecoxib in tablet formulation. The separation was achieved by Luna C 18 column and methanol: phosphate buffer pH 3.5 (60:40 v/v) as eluent, at a flow rate of 1.0 ml/min. Detection was carried out at 242 nm. Etoricoxib was used as an internal standard. The retention time of PAR and VAL was found to be 3.01 and 8.51 min, respectively. The method was validated for linearity, accuracy and precision. Linearity for paracetamol and valdecoxib were in the range 25-150 g/ml and 1-6 g/ml, respectively. The developed method was found to be accurate, precise, and selective for simultaneous estimation of paracetamol and valdecoxib in tablets.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded1044    
    Comments [Add]    
    Cited by others 6    

Recommend this journal