Indian Journal of Pharmaceutical Sciences
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Scientific Publication of the Indian Pharmaceutical Association
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Year : 2006  |  Volume : 68  |  Issue : 5  |  Page : 682-684

Application of orange G dye for quantitation of citalopram hydrobromide, donepezil hydrochloride and rabeprazole sodium from tablet formulation


Department of Pharmaceutical Sciences, M. L. Sukhadia University, Udaipur-313 001, India

Correspondence Address:
I Singhvi
Department of Pharmaceutical Sciences, M. L. Sukhadia University, Udaipur-313 001
India
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DOI: 10.4103/0250-474X.29652

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Three simple, rapid and accurate visible spectrophotometric methods have been developed using Orange G dye for the quantitative estimation of citalopram hydrobromide, donepezil hydrochloride and rabeprazole sodium from respective tablet formulations. These developed methods are based on formation of chloroform-extractable coloured complex of drug and dye. The extracted coloured complex shows absorption maxima at 476 nm and linearity in the concentration range of 10-50 μg/ml for citalopram hydrobromide (method I); at 482 nm and linearity in the concentration range of 5-35 μg/ml for donepezil hydrochloride (method II) and at 477.4 nm with linearity in the concentration range of 10-70 μg/ml for rabeprazole sodium (method III). The results of analysis for all three developed methods were validated statistically and by recovery studies.


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