| SHORT COMMUNICATION |
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| Year : 2007 | Volume
: 69
| Issue : 2 | Page : 309-312 |
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Pharmacokinetic evaluation of a developed nicotine transdermal system
Shaila Lewis, G Subramanian, S Pandey, N Udupa
Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, MAHE, Manipal - 576 104, India
Correspondence Address:
Shaila Lewis
Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, MAHE, Manipal - 576 104
India
DOI: 10.4103/0250-474X.33169
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The plasma concentration time profiles for nicotine were characterized after a single application of nicotine transdermal system to the upper fore arm of healthy smokers. A 12 cm2 system was applied for 24 h. Blood samples were withdrawn at predetermined time intervals. Plasma nicotine concentrations rose rapidly and achieved a mean Cmaxvalue of 14.5 ng/ml .The half life was estimated as 4.78 h and AUC(0-24)181.0 ng.h/ ml. The nicotine transdermal system was well tolerated. The results indicate that the system has potential usefulness in smoking cessation. The pharmacokinetic profiles of marketed patch system was compared with the developed system. Significant difference was observed in the pharmacokinetic parameters. |
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