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Year : 2008  |  Volume : 70  |  Issue : 4  |  Page : 445-449
A pilot cross-over study to evaluate human oral bioavailability of BCM-95® CG (BiocurcumaxTM), a novel bioenhanced preparation of curcumin

1 Arjuna Natural Extracts Ltd., R&D Laboratory, P.B No. 126, Bank Road Alwaye–683 101, India
2 Little Flower Hospital & Research Centre, Angamaly – 683 572., India
3 Life Extension Foundation, Florida, USA

Date of Submission09-Feb-2008
Date of Decision18-Mar-2008
Date of Acceptance17-Jul-2008

Correspondence Address:
B Antony
Arjuna Natural Extracts Ltd., R&D Laboratory, P.B No. 126, Bank Road Alwaye–683 101
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0250-474X.44591

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Curcumin, the bioactive component of turmeric, Curcuma longa has an exceptionally wide spectrum of activities including antioxidant, anti-inflammatory and anti-cancer properties, and is currently under different phases of clinical trials for various types of soft tissue cancers. However, although in vitro and animal studies have shown anticancer activities of curcumin for virtually all types of human cancers, its poor bioavailability in the human body has severely limited its application to these diseases. Methods to increase its oral bioavailability are a subject of intense current research. Reconstituting curcumin with the non-curcuminoid components of turmeric has been found to increase the bioavailability substantially. In the present clinical study to determine the bioavailability of curcuminoids, a patented formulation, BCM-95® CG was tested on human volunteer group. Normal curcumin was used in the control group. Curcumin content in blood was estimated at periodical intervals. After a washout period of two weeks the control group and drug group were crossed over BCM-95® CG and curcumin, respectively. It was also compared with a combination of curcumin-lecithin-piperine which was earlier shown to provide enhanced bioavailability. The results of the study indicate that the relative bioavailability of BCM-95® CG (Biocurcumax TM ) was about 6.93-fold compared to normal curcumin and about 6.3-fold compared to curcumin-lecithin-piperine formula. BCM-95® CG thus, has potential for widespread application for various chronic diseases.

Keywords: Curcumin, bioavailability, biocurcumax, Curcuma longa , anticancer, antioxidant

How to cite this article:
Antony B, Merina B, Iyer V S, Judy N, Lennertz K, Joyal S. A pilot cross-over study to evaluate human oral bioavailability of BCM-95® CG (BiocurcumaxTM), a novel bioenhanced preparation of curcumin . Indian J Pharm Sci 2008;70:445-9

How to cite this URL:
Antony B, Merina B, Iyer V S, Judy N, Lennertz K, Joyal S. A pilot cross-over study to evaluate human oral bioavailability of BCM-95® CG (BiocurcumaxTM), a novel bioenhanced preparation of curcumin . Indian J Pharm Sci [serial online] 2008 [cited 2016 May 6];70:445-9. Available from:

Curcumin, (diferuloylmethane; 1,7-bis[4-hydroxy-3-methoxyphenyl]-1,6-heptadiene-3,5-dione) along with its mono and di demethoxy derivatives, collectively called curcuminoids, constitute the major colouring matter and the biologically active constituents of Curcuma longa L. or turmeric. Ayurveda, Unani, Siddha and Chinese medicines recommend turmeric for a wide range of disorders and diseases. Modern science has provided a scientific basis for such uses [1],[2],[3],[4],[5],[6],[7] . Curcumin has been shown to be a very powerful antioxidant more potent than tocopherols, a comprehensive antiinflammatory, and an anti cancer compound beneficial in virtually all forms of human cancers, including cancers refractory to common anticancer drugs. Curcumin has been shown to enhance the effects of common anti-cancer drugs, and doses as high as 8 to 12 g per day have been shown to be well tolerated in humans [8],[9] . While all anticancer drugs weaken the immune system, curcumin enhances it and acts as an immunorestorer [10],[11],[12],[13],[14],[15],[16],[17],[18],[19] . Curcumin has been shown to be useful in a number of other chronic human ailments. For example, a human clinical trial is presently underway to test its efficacy in treating Alzheimer's disease [20] . Curcumin is able to modulate several molecular targets, including transcription factors, cell cycle proteins, cytokines and chemokines, a multitude of enzymes, receptors and cell surface adhesion molecules [21] .

In comparison with many diet-derived polyphenols and anti-cancer drugs, the bioavailability of curcumin has been poor [22],[23],[24],[25],[26],[27],[28],[29],[30],[31],[32],[33],[34] . For this reason, no clinical trial has progressed beyond the Phase I stage, and the wide range of physiological activities of curcumin has not yet been translated into clinical benefit. Poor absorption from the gut and avid metabolism in the body is cited as reasons for the lack of systemic availability. While the major portion of ingested curcumin is excreted through the feces unmetabolized, the small portion that is absorbed is extensively converted to its water-soluble metabolites, glucuronides and sulfate, and excreted. This seriously limits curcumin to reach targets distant from the gut and exert its beneficial action.

There have been sporadic attempts to increase the bioavailability of curcumin. Piperine, an inhibitor of UDP-glucuronosyltransferase, administered along with curcumin has been found to significantly enhance the plasma curcumin concentration in animals and in humans [35] . However, piperine is toxic in experimental animals [36],[37],[38],[39] . Other formulations are currently under development [40],[41],[42],[43] . While these developments are definitely encouraging, these require sophisticated technologies if and when they are fully developed. Such formulations are also unlikely to be cost-effective.

This study focused on a simple and cost-effective formulation, trademarked BCM-95® CG (Biocurcumax TM ), taking advantage of the synergism between the sesquiterpenoids present in turmeric and the curcuminoids [44] . Studies on experimental animals showed the efficacy of this formulation [45] . This communication presents the results on the relative bioavailability of normal curcumin and that of BCM-95® CG (Biocurcumax TM ) in human volunteers. The study also compares the relative bioavailability of BCM-95® CG (Biocurcumax TM ) with that of curcumin-lecithin-piperine formula.

   Materials and Methods Top

BCM-95® CG (Biocurcumax TM ) 500 mg capsules were supplied by Arjuna Natural Extracts Ltd. Curcumin capsules (control) and curcumin-lecithin-piperine capsules were supplied by Life Extension, USA and the standard curcumin for quantitation was obtained from Sigma Chemical Co., USA. Chromatographic solvents and all other chemicals were purchased from Merck.

Human subjects and study design:

This clinical trial was cleared by the Institutional Ethics Committee of the Little Flower Hospital, Angamali, Kerala, India on the request of the sponsor M/s Arjuna Natural Extracts Ltd, Kerala, India. Informed written consent from each of the prospective volunteers was obtained and after a medical examination those satisfying the inclusion and exclusion criteria, 11 subjects under the age group of 28-50 y were recruited for the study. The selected subjects were apparently healthy, and not diagnosed for any major diseases, as well as not presently taking any prescription medicines, and were not habitual users of tobacco and alcohol. The volunteers abstained from the consumption of aspirin or other NSAIDS and all foods containing turmeric two days prior to the study date.

Administration of BCM-95® CG (Biocurcumax TM ), curcumin and curcumin-lecithin-piperine formula:

The volunteers were divided into three groups of 4, 4, and 3 and admitted to the hospital day before the trial. After overnight fasting, group1 volunteers (4 numbers) consumed 4×500 mg capsules of BCM-95® CG (Biocurcumax TM ) while group 2 (4 numbers) and group 3 (3 numbers) consumed control curcumin and equivalent doses of curcumin-lecithin-piperine formula, respectively. Blood was drawn from each volunteer just prior to dosing and at 1, 2, 3, 4.5, 6 and 8 h post-drug. After wash out period of two weeks the subjects crossed-over to the other drug, i.e, group 1 subjects were administered control curcumin and the group 2 and 3 were consumed BCM-95® CG (Biocurcumax TM ) capsules. The same protocol was followed.

Extraction and quantitation of curcumin from plasma:

The blood (5 ml) was centrifuged at 2000×g for 10 min and the plasma was carefully drawn and collected in weighed tubes and the weights of plasma was recorded and were frozen till analyzed. Each sample of plasma (2.5 g) was allowed to attain room temperature and extracted with 3+2+2 ml ethyl acetate successively and the pooled extracts were filtered into evaporation tubes and the solvent evaporated to dryness under a stream of nitrogen at 40-45 o in a Turbo Vap Concentration Work Station (Caliper Life Sciences, USA). The dried samples were dissolved in 2 ml of methanol (HPLC grade) using a vortex mixer. It is then analyzed by HPLC in a Shimadzu LC 10AT Liquid Chromatograph System with SPD-10 A UV detector in isocratic mode. The column used was C 18 ODS Phenomenex (250×4.6 mm, 5 m particle size) with methanol as the mobile phase and the detection wave length 420 nm. Peaks were assigned in comparison with standard curcumin (Sigma). Curcumin was quantitated by using a calibration graph obtained from standard curcumin.

   Results and Discussion Top

There is an urgent need to find ways and means to enhance the bioabsorbability of curcumin so that its potential beneficial effects can be realized clinically. Results of the present study indicate that the proprietary formulation BCM-95® CG (Biocurcumax TM ) largely meets such a demand. The product at 2 g/day levels was well tolerated by all the volunteers who had participated in the study without even mild adverse reactions. The method of estimation of curcumin from blood plasma was validated by doing the recovery (80%) analysis. The peaks obtained for the curcumin reference standard as well as curcumin from the blood plasma were matched and typical plasma sample profile is shown in [Figure 1]. The concentration time profile of control curcumin versus BCM-95® CG (Biocurcumax TM ) is shown in [Figure 2] and that of curcumin-lecithin-piperine versus BCM-95® CG (Biocurcumax TM ) is shown in [Figure 3]. The values were analysed statistically by Anova and the difference shown by test and control groups were significant ( P <0.05). As evident from [Figure 2] the absorption of curcumin was faster from BCM-95® CG (Biocurcumax TM ) peaking in the first hour (mean 315.8 ng/g). This value dropped a bit during the succeeding hour at 274.6 ng/g and then reached the maximum at 4.5 h (456.88 ng/g). Thereafter the values gradually decreased. However, even at 8 h some residual curcumin remained in the blood. In contrast, the absorption of control curcumin was relatively slower, peaking at 2 h (149.8 ng/g) and then virtually disappeared from the blood by 4.5 h. Considering that one hour is too short a time period for the ingested curcumin to reach the intestine and then into blood, it may be speculated that at least part of the curcumin from BCM-95® CG (Biocurcumax TM ) is absorbed extra-intestinally. Apparently, this does not happen with ordinary curcumin.

BCM-95® CG (Biocurcumax TM ) may also probably modulate the Phase II enzymes due to its longer presence in the tissues and blood. Curcumin is simultaneously a substrate for these enzymes, an inducer of this enzymes as well as an inhibitor of these enzymes, depending on the context. However, which pathway is operating in individual cases is difficult to predict. Further, owing to its longer presence, curcumin from BCM-95® CG (Biocurcumax TM ) may modulate also the activity of the efflux pump, P-glycoprotein. All these activities may help to improve the absorption of curcumin from the present formulation compared to normal curcumin.

The pharmacokinetic data were arrived at using WinNonlin software [Table 1]. BCM-95® CG (Biocurcumax TM ) showed a mean t 1/2 (half-life) of 4.96 h, Ke (elimination rate constant) of 0.26 h -1 while the corresponding values for curcumin were 2.6 h and 0.296 h -1 , respectively. The area under the curve (AUC) of BCM-95® CG (Biocurcumax TM ) was about 6.93 times that of curcumin control meaning a bioavailability enhancement of 693% (Biocurcumax TM (AUC)-3201.28, Curcumin (AUC)-461.86). The bioavailability of BCM-95® CG (Biocurcumax TM ) versus curcumin-lecithin-piperine formula, as seen in [Figure 3], also shows an enhancement of 6.37. BCM-95® CG (Biocurcumax TM ) had better bioavailability than curcumin-lecithin-piperine formula, and well as a longer retention time compared to the latter.

The mean plasma concentration of curcumin from curcumin-lecithin-piperine formula reached a peak value of 344.32 ng/g and a Tmax of 3.5 h while the corresponding values for curcumin from BCM-95® CG (Biocurcumax TM ) were 689.18 ng/g and 4.67 h, respectively [Table 2]. The elimination rate constant (Ke) for curcumin-lecithin-piperine formula was 0.3372 h -1 compared to 0.139 h -1 of BCM-95® CG (Biocurcumax TM ), thus clearly establishing the difference between BCM-95® CG (Biocurcumax TM ) and curcumin-lecithin-piperine formula. The area under the curve (AUC) 0 to infinity for curcumin-lecithin-piperine formula was 624.26 units while that of BCM-95® CG (Biocurcumax TM ) was 3975 units. Thus, BCM-95® CG (Biocurcumax TM ) has a relative bioavailability of 6.37 compared to that of curcumin-lecithin-piperine formula. BCM-95® CG (Biocurcumax TM ) should also have a better safety profile because the composition is made entirely from turmeric in sharp contrast to the formulation containing piperine which is toxic to experimental animals [36],[37],[38],[39] . In our hands, this composition improved the bioavailability of curcumin only marginally.

Results of the present pilot study indicate that curcumin is absorbed early and retained longer from the BCM-95® CG (Biocurcumax TM ) composition compared to normal curcumin as well as from curcumin-lecithin-piperine combination. The results also indicate a probable role for the non-curcuminoid components of turmeric (especially Ar-turmerone) in the absorbability of curcumin in vivo.

   Acknowledgements Top

The authors deeply acknowledge Dr. T. N. B. Kaimal for his valuable suggestions and late Dr. S. B. Rao for his technical guidance when he was with them.

   References Top

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  [Figure 1], [Figure 2], [Figure 3]

  [Table 1], [Table 2]

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22 Anticonvulsant activity of bisabolene sesquiterpenoids of Curcuma longa in zebrafish and mouse seizure models
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23 Curcumin encapsulated in chitosan nanoparticles: A novel strategy for the treatment of arsenic toxicity
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24 Emerging role of nanocarriers to increase the solubility and bioavailability of curcumin
Chandana Mohanty,Manasi Das,Sanjeeb K Sahoo
Expert Opinion on Drug Delivery. 2012; 9(11): 1347
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25 Innovative Preparation of Curcumin for Improved Oral Bioavailability
Biological & Pharmaceutical Bulletin. 2011; 34(5): 660
[VIEW] | [DOI]
26 Comparative oral bioavailability advantage from curcumin formulations
Bhushan Munjal, Yogesh Bapurao Pawar, Sarsvatkumar Babulal Patel, Arvind Kumar Bansal
Drug Delivery and Translational Research. 2011;
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27 Dose-escalation and pharmacokinetic study of nanoparticle curcumin, a potential anticancer agent with improved bioavailability, in healthy human volunteers
Masashi Kanai, Atsushi Imaizumi, Yoshihiko Otsuka, Hiroki Sasaki, Momo Hashiguchi, Kazu Tsujiko, Shigemi Matsumoto, Hiroshi Ishiguro, Tsutomu Chiba
Cancer Chemotherapy and Pharmacology. 2011;
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28 Targeting NF-κB and HIF-1 Pathways for the Treatment of Cancer: Part I
Jacek Wilczynski, Markus Duechler, Malgorzata Czyz
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29 A novel solubility-enhanced curcumin formulation showing stability and maintenance of anticancer activity
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Journal of Pharmaceutical Sciences. 2011; : n/a
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30 Anti-arthritic effects and toxicity of the essential oils of turmeric (Curcuma longa L.)
Funk, J.L., Frye, J.B., Oyarzo, J.N., Zhang, H., Timmermann, B.N.
Journal of Agricultural and Food Chemistry. 2010; 58(2): 842-849
31 Prostacaid induces G2/M cell cycle arrest and apoptosis in human and mouse androgen-dependent and-independent prostate cancer cells
Yan, J., Katz, A.E.
Integrative Cancer Therapies. 2010; 9(2): 186-196
32 Protection of trabecular bone in ovariectomized rats by turmeric (Curcuma longa L.) Is dependent on extract composition
Wright, L.E., Frye, J.B., Timmermann, B.N., Funk, J.L.
Journal of Agricultural and Food Chemistry. 2010; 58(17): 9498-9504
33 The potential influence of plant polyphenols on the aging process
Cherniack, E.P.
Forschende Komplementarmedizin. 2010; 17(4): 181-187
34 Response to Kurien and Scofield: Solubility and bioavailability of curcumin
Aggarwal, B.B.
Trends in Pharmacological Sciences. 2009; 30(7): 335
35 Enhanced oral bioavailability and antioxidant profile of ellagic acid by phospholipids
Murugan, V., Mukherjee, K., Maiti, K., Mukherjee, P.K.
Journal of Agricultural and Food Chemistry. 2009; 57(11): 4559-4565
36 Response to Kurien and Scofield: Solubility and bioavailability of curcumin
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Trends in Pharmacological Sciences. 2009; 30(7): 335
[Pubmed] | [DOI]


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