Indian Journal of Pharmaceutical Sciences
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RESEARCH PAPER
Year : 2011  |  Volume : 73  |  Issue : 3  |  Page : 276-281

Preparation of evodiamine solid dispersions and its pharmacokinetics


1 The National Laboratory of Pharmacodynamics and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin 300193; Institute of Chinese Material Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China
2 The National Laboratory of Pharmacodynamics and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China
3 Institute of Chinese Material Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China
4 The National Laboratory of Pharmacodynamics and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin 300193; Tianjin Univeersity of Traditional Chinese Medicines, Tianjin 300193, China
5 Tianjin Univeersity of Traditional Chinese Medicines, Tianjin 300193, China

Correspondence Address:
C Liu
The National Laboratory of Pharmacodynamics and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin 300193
China
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DOI: 10.4103/0250-474X.93511

PMID: 22457550

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In order to increase the dissolution rate and bioavailability, solid dispersions of evodiamine in PVP K 30 with different enriched samples of evodiamine to PVP K 30 ratios were prepared by solvent method. Our studies showed that the dissolution rate of evodiamine was significantly higher in the solid dispersion system in comparison with that in enriched samples of evodiamine or physical mixtures. The increase of the dissolution rate was evidently related to the ratio of evodiamine to PVP K 30 . The solid dispersion system (enriched samples of evodiamine/PVP K 30 = 1/6, w/w) gave the highest dissolution rate: about 27.7-fold higher than that of enriched samples of evodiamine in hard capsules. Powder X-ray diffraction studies showed that enriched samples of evodiamine presented a total chemical stability after its preparation as solid dispersions. In vivo administration studies indicated that solid dispersions of evodiamine in hard capsules had a higher Cmax and a shorter Tmax than those of physical mixture in hard capsules, and the differences of Cmax and Tmax between them were significant. These results suggest that solid dispersions of evodiamine in hard capsules has a notably faster and greater absorption rate than enriched samples of evodiamine in physical mixture hard capsule and corresponds with the in vitro dissolution.


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