Indian Journal of Pharmaceutical Sciences
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Scientific Publication of the Indian Pharmaceutical Association
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Year : 2011  |  Volume : 73  |  Issue : 3  |  Page : 315-319

Extended Hildebrand solubility approach: Satranidazole in mixtures of dioxane and water


1 Department of Pharmaceutics, Shri Bhagwan College of Pharmacy, N-6, CIDCO, Aurangabad-431 003, India
2 Department of Pharmaceutics, Government College of Pharmacy, Vedant Hotel Road, Osmanpura, Aurangabad-431 005, India

Correspondence Address:
P B Rathi
Department of Pharmaceutics, Shri Bhagwan College of Pharmacy, N-6, CIDCO, Aurangabad-431 003
India
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DOI: 10.4103/0250-474X.93518

PMID: 22457559

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The extended Hildebrand solubility parameter approach is used to estimate the solubility of satranidazole in binary solvent systems. The solubility of satranidazole in various dioxane-water mixtures was analyzed in terms of solute-solvent interactions using a modified version of Hildebrand-Scatchard treatment for regular solutions. The solubility of satranidazole in the binary solvent, dioxane-water shows a bell-shaped profile with a solubility maximum well above the ideal solubility of the drug. This is attributed to solvation of the drug with the dioxane-water mixture, and indicates that the solute-solvent interaction energy is larger than the geometric mean (δ1δ2 ) of regular solution theory. The new approach provides an accurate prediction of solubility once the interaction energy is obtained. In this case, the energy term is regressed against a polynomial in δ1 of the binary mixture. A quartic expression of W in terms of solvent solubility parameter was found for predicting the solubility of satranidazole in dioxane-water mixtures. The method has potential usefulness in preformulation and formulation studies during which solubility prediction is important for drug design.


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