Indian Journal of Pharmaceutical Sciences
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Scientific Publication of the Indian Pharmaceutical Association
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Year : 2011  |  Volume : 73  |  Issue : 3  |  Page : 333-337

New 6-bromo-2-methyl-3-(Substituted Phenyl)-(3H)-quinazolin-4-Ones with Antimicrobial and Antiinflammatory activities


Department of Pharmaceutical Chemistry, Rajiv Academy for Pharmacy, Mathura-281 001, India

Correspondence Address:
Y Murti
Department of Pharmaceutical Chemistry, Rajiv Academy for Pharmacy, Mathura-281 001
India
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DOI: 10.4103/0250-474X.93512

PMID: 22457563

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New quinazolin-4-one derivatives, 6-bromo-2-methyl-3-(substituted phenyl)-(3H)-quinazolin-4-one, were synthesized and evaluated for antimicrobial and antiinflammatory activities. The structures attributed to synthesized compounds 1-8 were supported by the results of elemental analysis as well as by the UV, IR and 1 H NMR spectral data. Investigation of antimicrobial activity was performed using cup-plate agar diffusion method against Bacillus subtilis, Staphylococcus aureus and Pseudomonas aeruginosa and Candida albicans, Aspergillus niger and Curvularia lunata. Antiinflammatory activity was evaluated using the carrageenan-induced paw oedema test in rats. The results showed that compounds 2b, 2c, 2d, 2g and 2h exhibited significant antibacterial and antifungal activity comparable to standard drugs and compounds 2b and 2c showed good antiinflammatory activity comparable to ibuprofen.


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