| SHORT COMMUNICATION |
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| Year : 2011 | Volume
: 73
| Issue : 4 | Page : 478-482 |
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Synthesis and antimicrobial activities of some new azetidin-2-ones and thiazolidin-4-ones
Shobha R Desai1, UV Laddi2, Rajani S Bennur1, SC Bennur1
1 Department of Chemistry, S. S. Arts College and T. P. Science Institute, Old P. B. Road, Sankeshwar-591 313, India
2 Department of Chemistry, Channabasaveshwara Institute of Technology, N.H. 206, B.H. Road, Gubbi, Tumkur-572 216, India
Correspondence Address:
Shobha R Desai
Department of Chemistry, S. S. Arts College and T. P. Science Institute, Old P. B. Road, Sankeshwar-591 313
India
DOI: 10.4103/0250-474X.95654
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Various (4-substituted) phenyl-3-β-[(N-benzenesulphonyl/tosyl)-4-(un)substituted anilino]propionylamido-1,3-thiazolidine-4-ones (3a-x) and 1-β-[(N-benzenesulphonyl/tosyl)-4-(un)substituted anilino]-propionylamido-3-chloro-4-(4-substituted)phenyl-azetidin-2-ones (4a-x) have been synthesised by the cyclocondensation of Schiff bases (2a-x) with thioglycolic acid and chloroacetyl chloride, respectively. The structures of the newly synthesised compounds have been established on the basis of their spectral data and elemental analysis. All compounds were evaluated for antimicrobial activities against Escherichia coli, Bacillus cirroflagellosus, Aspergillus niger and Colletotrichum capsici. Most compounds investigated exhibited significant antifungal activity against Colletotrichum capsici, comparable to that of fluconazole, the standard used. |
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