The antifilarial activity of a synthetic agent, methyl-5 (6) piperidino-carbonyl benzimidazole-2-carbonate (C.D.R.I. Comp. No. 81/504) was evaluated against three different filarial species in rodents at various dose levels. It exerted 100 percent microfilaricidal action against Litomosoides carinii at 3 mg/kg, i.p. x 5 days in cotton rats and at 50 mg/kg i.p. x 5 days against Dipetalonema viteae and Brugia malayi in mastomys, on day 35,42 and 56 respectively. All the adults of L. carinii died at 10 mg/kg while worms of other two species, D. viteae and B. malayi were killed respectively at 12.5 and 50 mg/kg x 5 days. At 3000 mg/kg by oral route and at 300 mg/kg by i.p. route, the agent did not produce any untoward reactions in mice. The compound thus deserves further investigations.

N-Hydroxymethyl derivative of 2-phenyl-4-quinoline carboxamide was prepared and condensed with a few active hydrogen containing compounds (Salicylic acid. Beta-resorcilic acid, phthalimide, phenacetin and acetaminophen). N-hydroxy methyl derivative of cinchophen was found to be a potent analgesic and its product with salicylic acid and Beta-resorcilic acid showed good antiinflammatory activity.

A reproducible method for preparation of sustained release dosage form of Sulfisoxazole (SFX) was developed embedding the drug in formalized gelatin matrix. In vitro release profile of the drug was studied. Effect of the amount of Cetrimide (CTM) in the formulation was investigated.

A simple photometric method has been developed for the determination of prochlorperazine maleate (PCP) and trifluperazine HCI (TEP) in pure form and in pharmaceutical preparations. Aliquots containing 50-1000 mug/ml of sample and a known amount of 0.3N vanadium (V) reagent and 0.5 ml, 8N H2SO4 are heated in boiling water bath for 10 min till a permanent colour is obtained. The absorbance of this solution is measured at 680 m mu. Results are within +/- 1 percent error.

Pedilanthain, a new protease, was isolated from the latex of P.tithymaloides and was subjected to anti-inflammatory screening. Both dose-response and absorption characteristics were studied.

Solanogantine, a steroidal alkaloid isolated from the leaves of Solanum giganteum Jacq. exhibited dose dependent hypotensive effect in anaesthetised normotensive rats. It also revealed spasmolytic activity against known spasmogens in isolated smooth muscles. The hypotensive action appeared to be due to direct vasodilatation.

A series of N-methyl pyridiniumthiohydroximic esters have been prepared and evaluated in vitro with respect to their ability to reactive diisopropyl fluorophosphate inhibited acetylcholinesterase.

Sulphamethoxazole-N1-(methyl 2,3,4-tri-O-acetyl-Beta-D-glucuronide) was successfully synthesized and characterized by NMR and mass spectrometry for the metabolic study of sulphamethoxazole.

Simple, senstive and accurate spectrophotometric method for the quantitative determination of enfenamic acid (EA), piroxicam (PX) and naproxen [(NP), after demethylation] was developed based on the formation of a coloured oxidative coupling product with 2,6-dichloro0p0benzoquinone-4-chlorimine (gibbs reagent) in phosphate buffer (pH 7.0). The reaction is sensitive to permit the determination of 0.25 ppm of EA, 16 ppm of PX and 5 ppm of NP.