The release of ibuprofen from ointment bases through a dialysing cellulose membrane was studied. The drug release was greater from water soluble bases than other bases and was generally concentration dependent. The data obtained may be useful in the formulations of topical ibuprofen products.

In yeast, the low frequency of spontaneous occurrence of mitotic crossing over is increased several fold by ultraviolet irradiation. Since as a consequence of mitotic crossing over, the genes distal to the crossover become homozygous in fifty per cent of the nuclei resulting in the exposure of defective allels which were otherwise unexperessed due to heterozygous condition of the loci. In the present investigation, inhibition of post-replication repair by 0.1 per cent caffeine greatly reduced (63%) the frequency of UV-induced mitotic crossovers, thereby reducing the chances of occurrence of UV-induced genetic aberrations. Similar studies, if extended to higher systems such as mammalian cells in culture can be of great help in preventing ultraviolet –induced genetic aberrations in humans.

Electrochemical behaviour and analysis of alprazolam has been studied by differential pulse polarography over pH range 2.0 to 12.0. Both standard addition and calibration methods are used. The optimum pH range for the analysis of the alproazolam in different pharmaceutical formulation is found to be 4-6. The lower detection limit is 1.25x10-7 M.

A new series of 1-(N-heteroyl/diphenyl amino acety/propionyl) benzotriazoles (3a-h) and 4-(N-heteroyl/diphenyl/amino acetyl/propionyl) morpholines (4a-h) have been synthesized by appropriate methods. All the newly synthesized compounds were characterized by their microanalysis, IR 1H-NMR and mass spectra and were also screened for their anthelmintic and antimicrobial activities.

The volatile oil of Adenocalymma alliaceum (Bignoniaceae) composed of Diallyl di-, tri-, and tetrasulphides (5:5:1) showed antihypercholesterolemic activity comparable to that of clofibrate in diet-induced hypercholesterolemic rats.

A quantitative structure-activity relationship (QSAR) analysis of the binding activity data to the 5-HT1c and the 5-HT2 receptors for the congeneric series of phenylalkylamines was performed and the results there of revealed that the pharmacophoric requirements for both are nearly similar with only likely difference at 5- position of the phenyl ring. Further, for both subtypes, moderately hydrophobic substituent at 4-rign and less bulky groups at X are predicted to cause enhancement in potency of the ligand. A substituents at 2-ring appears to have synergistic influence.

In an attempts to develop mucoadhesive buccal drug delivery drug system, multilayered tablets of diltiazem hydrochloride were prepared which gave an in-vitro drug release of 86%. In-situ testing was done using bovine check pouch membrane in a Franz diffusion cell.

A quantitative thin layer chromatography (TLC) and high performance thin layer chromatography (HPTLC densitometry) procedures have been developed for the determination of prophyphenazone and ketoprofen in formulations. These two constituents were separated by TLC techniques followed by extraction of the components with methanol and the measurements of their absorption in UV range. The HPTLC determination was performed by modifying the solvent system developed for TLC and then scanning the spots by densitometry.

A simple, reverse phase high performance liquid chromatographic method was developed for the simultaneous determination of Paracetamol, Diclofenac Sodium and Chlorzoxazone from tablets. The method described is precise, accurate reproducible and rapid.

The dissolution test can be used to provide the formulation with valuable information for the design of dosage forms.1 Two marketed sustained release tablets, Product A and Product B, were evaluated for in vitro release using USP XX Type 2 dissolution apparatus at 37±0.5o for a period of 12hrs. Dissolution studies were carried out separately in three different buffers having pH values 1.2, 4.5 and 7.2, at three different paddle speeds, namely, 50,100 and 150 rpm at each pH.

In the fabrication of transdermal patches the cost of the pressure sensitive adhesive (PSA), including its applications, release and prime coating, often surpasses the price of the backing many times.1 Lalla et al.2 have earlier reported the synthesis and evaluation of polyacrylate pressure sensitive adhesive, the solubility of the drug in the adhesive and the fraction of drug unionized can be important factors affecting the skin permeation rates of drugs from adhesive matrix types transdermal system. Therefore, we have synthesized a neutral PSA (PSA I) and an acidic PSA (PSA II) by the method of solution polymerization. The formula are given in table I.