Nitrofurantoin bearing microspheres of wax were prepared by wax emulsification and congealing techniques. The effects of emulsifier concentration and stirring rate on drug release and other physical parameters of microspheres were studied. Based on in vitro release and urinary excretion data nitrofurantoin wax microspheres appeared to have sustained drug release profile. Bees wax and hard paraffin have been used in the preparation of matrix embedded sustained release formulations of drugs. In the present investigation NFT (nitrofurantoin) was embedded in spherical monoliths of wax prepared by emulsification of wax its subsequent congealing. The variables studied were : stirring rate, emulsifier concentration and drug loading. The effects of these variables on particle size, shape and degree of drug embedding were also studied. The formulation with desirable release rate was selected. The in vivo performance of NFT-wax microspheres was evaluated using urinary excretion profile obtained on dogs.

The title compounds (III) have been prepared by cycloaddition of diazomethane to 3-aryl-2-styryl-4 (3H)-quinazolinones (II) in dry ether. Their structures have been elucidated on the basis of elemental analysis and spectral data (IR, PMR and mass). Some of these compounds have been found to exhibit good antifungal activity.

Solid dispersions of ibuprofen were prepared by fusion using PEG 4000, PEG 6000, mannitol, urea, sorbitol, dextrose, sucrose and their mixtures as carriers in (1;1). Interaction/stability of the drug with carriers in solid dispersions was tested by UV scanning, TLC and Infra-red analysis.q. The results reveal that solid dispersion of Ibuprofen : mannitol-urea gave satisfactory results.

Fifteen N-acridin-9-yl-N'- alpha-aryloxypropionyl hydrazines have been prepared and screened for their antifungal activity against three fungi, viz. A. niger, H. oryzae and C. sacchari. All of them were not as active as the central agent Blitox-50 W.P.

A senstive, specific and rapid HPLC procedure has been developed for the detection and determination of urine levels of 1- and 2-naphthols. Urine samples were adjusted to pH 1.5 and extracted with dichloromethane. Separation on a HPLC micropak CN-10 column with a fixed wavelength U.V. detector (254 nm) and hexane : dichloromethane : isopropylalcohol (89 : 10 : 1) as solvent system allowed the measurement of 1-naphthol at 100 ng ml(-1) and 2-naphthol at 50 ng ml(-1) levels.

A new spectrophotometric method for the estimation of Sotalol Hydrochloride (SH) based on its reaction with Folin-ciocalteu reagent in presence of sodium carbonate solution is described here. The complex has a maximum absorbance at 725 nm and obeys Beer's law in the range of 0.8-40 mcg/ml. The method is statistically validated and results compare favourably with those obtained by reported method.

Eight substituted-2-amino-8H-Indeno [1, 2-d] thiazoles have been synthesised by condensation of various substituted indanones with thiourea and iodine. These have been tested for antiinflammatory activity against carragenan-induced oedema in rat paw and some of them show moderate activity.

Three simple, rapid and senstive spectrophotometric methods are described for the determination of procainamide hydrochloride in bulk samples and pharmaceutical preparations, based on the coupling of the diazotised drug with the reagents such as chromotropic acid, phloroglucinol and ethylacetoacetate to give coloured products having maximum absorbances at 480 nm, 415 nm and 420 nm respectively. The results are reproducible within +/- 1.0 percent

A condensation of four different 3-formychromones with 2-methyl/phenyl-3-amino-4 (3H)-quinazolinone and their dibromo analogs has resulted in twelve new compounds which have been characterized as their respective 3-[N-(4-oxo-2-methyl/phenyl-3-quinazolinyl) formimidoyl] chromones, based on their spectro-analytical properties. They have been found to exhibit promising antibacterial and antifungal properties.

The extent of a absorption of grissofulvin (500 mg) from oil-in-water (O/W), water-in-oil-in-water (w/o/w)emulsions and tablet dosage forms were determined and compared following oral administration of each of the dosage forms, in a crossover fashion, to 8 healthy volunteers. The absorption characteristics were assessed by measuring the urinary excretion of the major metabolite of griseofulvin (6-desmethylgriseosulvin). From these results, it is suggested that the administration of griseofulvin in the W/O/W emulsion may lead to the enhancement of therapeutic efficacy of the drug in man.

Cellulase from Aspergillus niger was used to hydrolyse carboxymethylcellulose (CMC) present in the fortified procaine pencillin formulation. The filtration time during the sterlity test was reduced from 300 min to 4 min. The approach can be extended to sterility testing of other pharmaceutical preparations containing CMC as an ingredient.