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A new simle and rapid spectrophotometric method for the determination of diclofenac sodium is described. Diclofenac Sodium gives yellow colour when reacted with sodium nitrite in the presence of HCI with a maximum absorbance at 390 nm. The Beer's law is obeyed in the range of 0.05-0.60 mg of diclofenac sodium.

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Total methanolic (90 percent) extract of Boygainvillea glabra leaves was fractionated by different solvents and the fractions were tested for their anti-inflammatory action in carragenin rat paw oedema. Only petroleum-ether (60-80 degree) fraction showed significant activity when given intraperitoneally at a dose of 100 mg/kg. The choromatographic studies of the petroleum-ether fraction indicated that the anti-inflammatory activity was due to the presence of steroidal component in the leaves.

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Polymers and copolymers of acrylic series were synthesised and drug embedded matrices were prepared by common solvent solution evaporation technique. Suspension adjuvants were blended with the fine particles of drug embedded matrix and the formulated suspension of alpha-methyl dopa was investigated for in vitro release and stability. Results indicated possibility of preparing a sustained release dry suspension of alpha-methyl dopa.

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Solanine, a steroidal glycoside, is the major alkaloid of potato plant, which is toxic to insects at higher concentrations. In the present study callus tissues of Solanum tuberosum and S. dulcamara (Solanaceae) have been worked out qualitatively and quantitatively for their solanine content.

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The botanical identity of the commercial drug sold under the name jungle pepper in the madras crude drug market has been determined as Vitex pubescens Vahl. A detailed phytochemical investigation of this drug gave five compounds, viz., n-octacosanol, ursolic acetate, stigmasterol, Beta-sitosterol and ursolic acid.

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Mahua seed kernel contains 43.3 percent fat with a melting point of 36.5-38 degree. Suppository bases were formulated using different percentages of mahua fat, beeswax and spermaceti. Percentages boric acid and salicylic acid releases from these bases were compared with those from cocoa butter. Rheological and stability studies of the bases were also performed.

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Four commercial naproxen tablets were compared for their bioavailability in a complete cross-over study in human subjects. A significantly higher naproxen dissolution and bioavailability was obtained for one brand of its tablet (NX).

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Ten new N-(aryl/coclohexyl thiocarbomoyl) sulfaniyl 2-(2-benzothiazolyl) hydrazides have been prepared and evaluated for their oral hypoglycemic activity against the streptozotocin-induced diabetic rats. One of them (IVi) has been found to be efficent in reducing the blood sugar levels.

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Drug interactions of antipyretics, analgesics, vitamins, antidiabetics and antihistamines with ampicillin was studied by the dilution method using E. coli and Staph. aureus. The results showed that except in certain cases where absence of interaction was noted down, most of the drugs tested showed antagonistic or synergetic interaction with ampicillin.

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Tolnaftate (TF) in cream and topical solution was determined by reverse phase HPLC on Partsil-10-ODS column, acetonitrile plus propan-2-ol plus 0.1 N aq. sodium acetate plus water (43:6.2:1:5) as mobile phase, U.V.detection at 254 nm and testosterone valerinate (TV) as internal standard.

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Chemotherapeutic properties of Toluidine Blue, a basic dye have been studied against Gram positive, Gram nagative bacteria, Candida albicans and two transplantable tumour strains of Swiss mice like Ehrlich Ascites Carcinoma and Sarcoma 180. The dye was found to have antibacterial, antifungal and substantial antitumour activities. The LD50 value of Toluidine Blue is 275 mg/kg body weight in albino mice by the intraperitoneal route (i.p.).

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Flurinated 4-imino-3,5,7-trisubstituted pyrido [2,3-d] pyrimidine-2 (1H)-thiones were prepared by 2-amino-3 cyano-4, 6-disubstituted-pyridines and appropriate arylisothiocyanates, and characterised. The antibacterial activity of all the pyrido[2,3-d]-pyrimidines has been evaluated and found active against S.aureas.

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Cyclocondensation of 3-aryl/5-methyl 1-2-hydrazinoimidazol-4-ones II (a-c) with 2,4-dichloro-phenoxy acetic acid, HCOOH, CICO2 ET and CS2 furnished a novel class of compound 7-aryl/5-methyl imidazo [2,1-c] -1,2,4-triazol-6-one and their analogues [III-VI (a-c)]. These have been compared with Diathane M-45, for their antifungal activity against A. niger and F. oxysporum.

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Microbial kinetics have been employed to study the mechanism of antibacterial activity of chloroquine on S. aureus. Cultures treated with the drug in growth medium showed biphasic steady-state generation curves, the apparent rate constant for the phase I was smaller than for phase II. The bacteriostatic activity of the drug was associated with the first phase of drug-bacteria reaction, which was also affected by changes in pH of the growth medium.

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A series of 7-ethoxy-4-substituted aminomethylcoumarins have been synthesised making use of the selective reactivity of methyl and formyl groups in position-4 of coumarin nucleus. All these compounds have been screened for their antibacterial activity. Compounds with anilinomethyl, picolinylaminomethyl function in position-4 of coumarin ring system showed higher inhibition of bacterial growth. The other compounds showed only moderate activity.

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Imidazole was found to reduce urinary ascorbic acid excretion in rats unlike SKF 525-A. During one week daily treatment with imidazole (50 mg/kg, I.P.), ascorbic acid excertion was gradually reduced and the maximum reduction was 7.58 percent. With a single higher dose (100 mg/kg. I.P.) the reduction was 27.8 percent and was maintained later with further treatment. With SKF 525-A (50 mg/kg, I.P.), the ascorbic acid excretion was increased by 23.6 percent with a single dose and was raised to 68.54 percent after four doses which was maintained later on further treatment. The change produced in ascorbic acid excretion in rats by these substances was statistically significant.

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Certain new carbothioamide and thiadiazolidine derivatives were synthesized and evaluated for antibacterial activity against grampositive and gramnegative bacteria. MIC Values for the carbothioamides ranged from 600-16-- mug/ml although corresponding thiadiazolidine derivatives were effective antibacterial agents.

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A new series of 4-quinazolone i.e. 1-deoxy-1-(alpha-substituted-3-amino/methylamino-4-quinazolono)-D-fruc tose have been synthesized by refluxing oxalate salt of 3-amino-4-quinazolone and anhydrous D-glucose, with a view to observe the effect of aldose and amines linkage on central nervous system. The compounds were tested on albino mice of both sex. Some of them showed CNS depressant effect.

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