Twelve natural gums and mucilages were evaluated for their ability to sustain the release of drug from matrix systems. Mucilages from pods of Hibiscus esculenta and seeds of Linum usitatissimum are found to possess better sustaining characterstics than even widely used synthetic materials like methyl cellulose (Mc), sodium carboxymethyl-cellulose (NaCMC) and hydroxy propylmethylcellulose (HPMC).

[ABSTRACT]   Full text not available   

Betulin aldheyde together with lupeol, betulin and betulinic acid have been isolated from the stem bark of Tectona grandis and characterised by spectral analysis. This is the second report of the natural occurrence of betulin aldehyde.

[ABSTRACT]   Full text not available   

Ethanol extract of leaves and fruits of some arid zone plants afforded quercetin and kaemoferol as major flavonoids. The maximum total flavonoids content (8.50 mg/gdw) was found in leaves of Leucas urticaefolia and minimum (1.85 mg/gdw) in fruits of abutilon pannosum.

[ABSTRACT]   Full text not available   

Full text not available   

A new ptoteolytic enzyme was extracted from the latex of Jatropha curcas and it was mnamed "curcain". The isoelectric point of the enzyme was determined and the proteclytic activity studied with milk, and casien as substrates. The temperature and pH for optimum activity and effect of some activators and inhibitors on its activity is reported.

[ABSTRACT]   Full text not available   

When the drug (N-isobutyl-4,5 decadienamide) was tested for analgesic activity using the tails of albino rats, applying thermal method (Hotwire) and analgesiometer, it showed significant activity.

[ABSTRACT]   Full text not available   

Monoene and diene bhilawanols isolated from Semecarpus anacardium nut extract inhibited gram positive anaerobes. ED 50 and ED 95 values obtained turbidometrically against seven different species of anaerobes was in the range of 0.3 to 10 mcg/ml. Studies on probable mechanism of action are discussed.

[ABSTRACT]   Full text not available   

The isolation and characterisation of beta-sitosterol, Beta-amyrin, quercetin, kaempferol, rutin, and iridoids plumieride, plumeiride coumarate and plumieride coumarate glucoside from the flowers of Allamanda schotii is described.

[ABSTRACT]   Full text not available   

Degradation of aqueous solution of several semi-synthetic penicillins viz. ampicillin, hetacillin, phthalimido penicillin as well as sulfoxides of benzylpenicillin, phthalimide penicillin and ampicillin, in presence of copper (II) ions has been studied following UV-visible spectrophotometric method. Based on these results, comparative studies have been made to evaluate the role of metal ion in affecting the two major pathways responsible for penicillin degardation.

[ABSTRACT]   Full text not available   

The interaction of pentobarbitone and diazepam with ephedrine and caffeine was evaluated. Ephedrine was found to potentiate and caffeine reduced sleep time of both the C.N.S. depressants. Indomethacin reversed the effects of ephedrine. Reserpine potentiated the effects of pentobarbitone and diazepam but reserpine pre-treatment reduced the effects of ephedrine which may probably be due to non-availability of catecholamines-stores. Phenoxybenzamine significantly counteracted the action of hypnotics and propranolol potentiated.

[ABSTRACT]   Full text not available   

The adsorption of phenforim hydrochloride from aqueous solution on bentonite, montmorillonite, kieselgurh, china clay, fullers earth and Kaolin N.F. was studied. Bentonite and montmorillonite were found to possess adequqte adsorption capacities and hence their complexes with drug were subjected to drug content analysis and dissolution rate studies. Based on these studies, sustained release formulations were made and subjected to in-vivo evaluation using fall in blood sugar level of alloxan induced diabetic rabbits. Duration of action was found to be 10 to 11 hours.

[ABSTRACT]   Full text not available   

Two senstive methods for the determination of diethylcarbamazine citrate, bephenium hydroxynapthoate, tetramisole hydrochloride and levamisole hydrochloride based on the formation of coloured complexes of the drug with reagents such as fast green FCF at pH 5.0 or orange-II in presence of O.IN HCI are described in bulk samples and pharmaceutical preparations. The ion-pair complexes foemed are quantitatively extracted into chloroform under the experimental conditions.

[ABSTRACT]   Full text not available   

A spectrophotometric method for the estimation of sulphacetamide based on its reaction with o-Chloranil at pH 9.0 yielding a purple coloured chromogen with absorption maximum at 525 nm is reported. Beer's law is obeyed over the concentration range 10 to 70 mug/ml of sulphacetamide sodium. The proposed method is applicable to pharmaceutical preparations.

[ABSTRACT]   Full text not available   

Spectrophotometric methods based on the reaction with vanillin in methanol in phosphoric acid medium and Folin-Ciocalteu reagent in strongly acidic medium are reported for the determination of nifedipine and its dosage forms. The chromagens obtained have absorbances maxima at 400 nm and 740 nm and obey Beer's law in the concentration range of 10-180 mcg/ml and 6-100 mcg/ml respectively.

[ABSTRACT]   Full text not available   

Gums obtained from Cochlospermum gossypium, Anogeissus latifolia and Buchanania lanzam and their carboxymethyl and methoxyl derivatives when studied for their binding properties suggest that gums of the first two plants and their derivatives particularly the carboxymethyl derivative, could be employed as binding agent in pharmaceutical practice.

[ABSTRACT]   Full text not available   

Noscapine was formulated into timed-release microcapsules so as to have the effect of the drug for 8 hours. Nonpariel seeds were chosen as the drug carrier and Eudragit-L and Eudragit-S as coating materials. Uncoated and 12-coated microcapsules were mixed and filled in hard gelatin capsule for the final dosage form.

[ABSTRACT]   Full text not available   

Metal chelates of plumbagin (2-methyl-5-hydroxy-1,4-naphthoquinone) with aluminium, iron, cobalt, nickel, copper and uranium were synthesised and screened for antimicrobial activities. Metal chelates of aluminium, cobalt and uranium showed considerable antimicrobial activity.

[ABSTRACT]   Full text not available   

A simple and sensitive fluorimetric procedure is described for the analysis of pyrimethamine in dosage forms depending on its strong fluorescence in 1 normal sulphuric acid (lamda excitation = 321 nm, (lamda emission = 425 nm) with a detection limit of 1 mug/ml. The addition of molecules of sulfodoxine cause a quenching in the region of excitation and emission of the former compound.

[ABSTRACT]   Full text not available   

1-(2-Furanyl)-3-aryl-2-propenones (I) were cyclised with substituted phenyl hydrazines yielding 1-aryl-5-(2-furanyl)-4,5-dithydro-3-(substituted phenyl)-1H-pyrazoles. The double bond of I was brominated which yielded a dibromo compound (III). (III) on reaction with secondary amines yielded 1-(2-furanyl)-3-substituted-1, 2-disubstituted-3-propanones. The mass and NMR spectra have been discussed. The compounds were screened for acetylcholinesterase inhibitory activity as well as the anthelmintic activity against H. nana.

[ABSTRACT]   Full text not available   

A new method for the milligram determination of pyrimethamine in pure form and in pharamaceutical preparations has been developed within the accuracy of +/- 1 percent error. Drug samples (1-5 mg) are reacted with excess of N-chlorosuccinimide (NCS) in acidid medium at room temprature (25 degree) for about 15 min. The excess of the reagent is determined iodometrically.

[ABSTRACT]   Full text not available   

Effect of pH on the stability of aqueous solution of butaperazine is studied. The solution is found to be stable most at pH 6.

[ABSTRACT]   Full text not available   

The condensation of 3-formychromones with N-alkyl/arakyl-3-nitro-o-phenyle-nediamines has been studied under two different experimental conditions. The products have been characterized by their analytical and spectral data and evaluated for their CNS, analgesic and anti-inflammoary activity, in experimental animals.

[ABSTRACT]   Full text not available