Wool grease or lanolin contains upto 15 percent cholesterol in the form of its ester. This cholesterol can be isolated from the wool grease by several methods, of which three were tried and their comparative yields noted to be significantly different. The isolated cholesterol was purified and evaluated for its properties.

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[Chemical analysis of Prunus persica heart wood resulted in the isolation of beta-sitosterol and its D-glucoside, hentriacontane, hentricontanol and the flavonoids naringenin, dihy-drokaempferol, kaempferol and quercetin.

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During screening of leaves of some higher plants for their activity against Trichophyton rubrum and Epidermophyton floccoccum, the leaf extracts of Artemisia nilagrica were found to exhibit fungitoxicity. The volatile antifungal factors were isolated in form of essential oils. Minimum concentration of the oil for absolute inhibition of test fungi was found to be 250 ppm, at which it showed fungistatic nature and broad fungitoxic spectrum.

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The bioavailability of microcrystalline tablet and macrocrystalline capsule forms of nitrofurantoin increased when administered with food. In both fasting and nonfasting subjects the maximum excretion rate of macrocrystalline in fasting state only. Enhanced absorption of nitrofurantoin with food was attributed to the greater motility of small intestine and accelerated gastric emptying with the diet used.

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An extractive colorimetric method for the determination of dothiepin hydrochloride from pharmaceutical preparations is described. The method is based on the formation of ion-pair complexes of the drug with reagents like bromophenol blue (BPB), bromothymol blue (BTB), bromocresol purple (BCP) and bromophenol red (BPR) in acidic medium. The ion-pair complexes formed are quantitatively extracted in chloroform. The method is statistically validated and is found to be precise and accurate.

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Partition coefficients of diloxanide furoate and some of its related analogs have been determined. Interaction of diloxanide furoate with blood phospholipid has been studied and explained in relation to the partition coeffcient values.

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Shellac-glycerol reaction intermediates were prepared. Tablets were prepared using solutions of these esters as anhydrous binding agents (3.5) and evaluated. The esters exhibited excellent binding properties, imparting hardness to the tablets. The t50 for shellac and SG-33 (acid value 33) is 30 and 28 min. respectively. For other esters t50 lies between 38 to 57 min.

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Substituted 1-chloro/bromo-2, 3-dihydroxy-4-undecylphenazines were synthesized by the condensation of chloro/bromoembeline with substituted o-phenylenediamines and screened for antitubercular, antibacterial and antifungal activities.

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An extractive colorimetric method for the determination of ketoconazole from pharmaceutical preparations is described. The method is based on the formation of ion-pair complexes of the drug with reagents like bromocresol green (BCG), bromocresol purple (BCP) < bromophenol blue (BPB) and bromophenol red (BPR) in acidic medium. The ion-pair compexes formed are quantitatively extracted in chloroform. The method is statistically validated and is found to be precise and accurate.

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A series of new 5(6)-[2-arylthiazol-4-yl] benzimidazole-2-carbamates (21-26 & 27-32) have been synthesized and screened for their anthelmintic activity.

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Diazepam in 0.5N hydrochloric acid exhibites intense fluorescence with lamda max 500 nm. This forms the basis for the fluorimetric method developed for bulk drug and formulations.

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Bagasse at a level of 5 percent has been found to be a good disintegrant for direct compression of tablets.

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A semimicro-titrimetric method for the determination of chlorpropamide based on ashing and determination of its sulphur content is reported. The proposed method can be adopted in quantities ranging from 10-60 mg authentic drug with a mean recovery of 100.16 +/- 0.78 percent and the results are comparable with those of the BP 1980 method.

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Several 1-(substituted thioanilido)-8-Keto-3-substituted benzopyridazines (III) were readily synthesized by cyclodehydration of corresponding 4-aryl thiosemicarbazones (II) which were prepared by condensation of either 2-carboxy benzaldehyde or 2-carboxy benzophenones with 4-aryl thiosemicarbazides. Twenty-one such compounds have been tested for general pharmacological properties on cardiovascular system in guinea-pigs. These compounds were found to have positive inotropic activity in vitro.

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Various ring substituted cinnamic acid (CA) derivatives were evaluated for antifertility effect in female albino rats at a dose of 40 mg/kg., i.p., given daily from days 1 to 10 of pregnancy. 3-Nitro-CA., 3,4-dichloro-CA. and CA inhibited pregnancy in 50 percent rats. Rats treated with 3-nitro-CA showed high amount of resorbtion of fetus.

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Substituted methyl 1-acetoxy-3-napthoates were prepared. They were evaluated for antiinflammatory, analgesic and antipyretic properties, several of them showed statistically significant activities compared to standard NSAIDS. The ED50 and LD50 of the two most active compounds showed them to be potentially therapeutically useful.

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Antibacterial activity of thirteen substituted phenylbutenones was studied. Regression analysis showed that for the activity against B. subtilis hydrophobicity and electronic parameters are importent. A parabolic model was obtained with hydrophobicity and antibacterial activity against E. coli.

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