The method of analysis of the title compounds is based on the oxidation of calcium gluconate, mannitol and sorbitol with sodium periodate to liberate formaldehyde which is reacted with acetylacetone in presence of ammonium acetate to give yellow coloured product having maximum absorbance at 412 nm.

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A simple HPLC method for the simultaneous determination of Oxyphen-butazone, Chlorzoxazone and paracetamol using caffeine as an internal standard is described. The assay was carried out using mu Bondapack (C18) column and methanol : ammonia (40 : 60 : 0.1) as mobile phase. The elute monitored with a 240 nm detector.

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A HPLC method is presented for simultaneous determination of Spiranolactone and Frusemide (furasemide) in pharmaceutical dosage forms on C18 column using a binary mixture of acetonitrile : 0.05M phosphate buffer (15:85) v/v as a mobile phase. The method was applied for the assay in tablet and capsules and the mean recoveries are 99.39 percent (SD +/- 0.91- for spiranolactone and 100.54 percent (SD +/- 1.36) for frusemide indicating high accuracy and precision of the method.

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A rapid, precise and accurate HPLC analysis is presented for the simultaneous determination of Furazolidone and Metronidazole in pharmaceutical dosage forms. Mean recoveries for Furazolidone and 100.53 +/- 0.83 respectivery and Metronidasole were 99.58 +/- 0.69.

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A rapid HPLC method was developed for the simultaneous determination of muzolimine and reserpine in mixtures. Seperation was achieved with a mu Bondapak phenyl column and methanol - water mixture (100 : 5 v/v) as eluent. The method is simple and accurate.

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A simple, rapid and senstive spectrophotometric method is described for the determination of tropane alkaloids from plant extract which gives yellow color complex with bromo phenol blue (BPB) in buffer medium at pH 3.5. The absorbance was measured at 411 nm.

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OPTICALLY active fatty acid hydrazides and the phenyl hydrazides of ricinoleic and chaulmoogric acid were prepared. The reduction of these compounds by hydrazine hydrate under different conditions (Molar ratios 1 : 3, 1 : 4, 1 : 5; temperatures 50 degree C and 60 degree C) were studied to establish the effect of temperature, molar ratio and phe l group on their optical activity and iodine values during the course of reduction by hydrazine hydrate. The rate of reduction was found to increase with increasing temperature and molar ratios of fatty hydrazide to hydrazine hydrate. The decrease in iodine values were comparatively less in comparison with the reduction of fatty acids by hydrazine hydrate.

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The influence of deficiency and toxicity of Fe, Mn, Cu, Zn, and B supplies have been studied in Artemisia annua grown in sand culture in glasshouse. A annua is highly sensitive to deficiency of B followed by Fe, Zn, Cu, and Mn which significantly decreased growth and artemisinin content. Higher supplies of B and Fe significantly increased herb yield, whereas Cu and Mn were inhibitory. Fresh and dry yield of herb were significantly positively associated with artemisinin content.

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An extensive computer programming in BASIC LANGUAGE is performed to compute the drug release data obtained from the in vitro dissolution studies of different microcapsules to fit the order of the equations in the light of different Kinetic Models. With the help of Linear Regression Analysis the corelation coefficients have been derived from the equations for zero order, matrix and first order release mechanism to predict the actual order of the release kinetics. Finally the diffusivity rate constant ((KBL) and diffusion coefficient (Da) have been evaluated with help of Baker Lonsdale equation when the matrix mechanism predominates.

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In vitro protien binding interaction between H2 blockers such as ranitidine and famotidine with two non-steroidal anti-inflammatory drugs (NSAIDS) ibuprofen and piroxican were studied by equilibrium dialysis method. Ibuprofen and piroxicam exhibited strong binding (70.05 percent and 86.05 percent respectivelyy) with bovine serum albumin. From the results obtained, no significant variation was observed in protein binding of ibuprofen and piroxicam in the presence of ranitidine and famotidine.

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A capillary GLC method has been developed for the estimation of ibuprofen in tablets using flame ionization detection. No derivatization of the drug was required. The results were compared with the official (IP) method.

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Quaternary ammonium and alkali metal salts of Hamycin have been prepared by ion-exchange method and their physico-chemical as well as biological properties were studied. Unlike other polyene macrolide salts, triethyl ammonium salt of Hamycin appeared to have some therapeutic advantages over the parent compound, while retaining its bio-activity intact. The alkali metal salts, on other hand were converted to the less toxic esters at a moderate yield on treatment with alkyl halides in presence of a phase transfer catalyst.

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Quantitative structure activity relationship (QSAR) studies of a new series of aryloxypropanolamines possessing beta adrenoceptor blocking and hypotensive activities were undertaken so as to evaluate the influence of hydrophobic binding and steric factorson their beta adrenergic blocking activity. The results indicate that seric factors have a greater influence on their biological activity. The activity dropped considerably when the semicarbazone chain was substituted with aromatic substituents. The existence of an optimum lipophilicity and limited steric freedom for ortho substituted aryloxypropanolamines is indicated.

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Terbutaline sulphate in distilled water exhibits intense fluorescence at 315 nm when excited at 280 nm. This forms the basis for the fluorimetric method developed for the dosage forms.

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