The water soluble gum isolated from the seeds of Cassia fistula Linn. found in abundance throughout India, has been evaluated for its binding properties for formulations of tablets containing 2 and 4 percent of gum. The binding properties of gum has been evaluated in relation to the conventional binders like Gum arabic, Gum tragacanth, Sodium CMC and Gelatin at different parameters like percentage of fines, tablet hardness,disintegration time and friability. Thr gum showed overall superiority in viscosity and binding properties as compared to other binders. The addition of preservatives effectively checked the gum's characteristic of losing viscosity on keeping. Like other binders,increase in concentration of gum from 2 to 4 percent, decrease the percentage fines (5.6 to 3.45), increase the hardness (kg/in2)5.11 +/- 0.7270, C.V.14.22 percent to 5.98 +/- 0.6863, C.V.11.47 percent)and disintegration time (30 min 29 sec to 36 min 44 sec). Percentage friability has been found to be almost equal (0.81 and 0.84) in Cassia gum although it was increased in other samples except gum tracanth. The results indicate that C.fistula seed gum is a potential binder for pharmaceutical industry.

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Phyllanthin and Hypophyllanthin are ligan constituents isolated from Phyllanthus niruri. When tested on various cancer cell lines these compounds did not show significant cytotoxic effect on any cell line.

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A fast, accurate,rugged and simple High Performance Liquid Chromatographic (HPLC) method has been developed for simultaneous quatitation of enalapril maleate and hydrochlorthiazide in pharmaceutical formulations. The column used was reversephase (ODS). The assay result obtained for a commercial formulation was in accordance with the label claim. The results of the method was statistically validated for its accuracy, reproductibility and precision, by interday-intraday analysis. The low value of co-efficient of variation (0.94-3.06 percent) confirm the ruggedness of the method.

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The stability of fast and slow release compressed propanolol HCL suppositories was evaluated at room temprature (RT) and at accelerated temprature 37 degree & 45 degree C for 8 weeks. There was no degradation of the drug at 25 degree C, and 37 degree C, with only 6-7 percent degradation of the drug at 45 degree C by the end of 8 weeks. After 8 weeks of storage,slight changes in the in-vitro release of the drug from conventional suppositories and about 5-6 percent slowening from slow release suppositories was observed at 45 degree C with no changes at other temprature studied.No change in the hardness of the suppositories was observed after storing for 8 weeks at RT and elevated temperatures.Accelerated stability data of 8 weeks revealed that the compressed propranolol HCI suppositories were physically and chemically stable.

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The effect of alcholic and water extract of the aerial parts of Euphorbia dracunculoides on increase in gastric emptying and intestinal transit of rats was observed to be significant. The effect was observed to be more pronounced in alcholic extract in comparison with that of the water extract.

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Life-span of mice treated with a chronic lethal dose of cyclophosphamide was considerably increased by the simultaneous administration of turmeric extract or curcumin (40.8 percent and 91.7 percent respectively ). Similarly leukoplnia produced by cyclophosphamide was reduced by these agents but lowered haemoglobin levels remained unaltered. Increased glutamate-pyruvate transaminase, alkaline phosphates and thiobarbituric acid- reacting material in the liver were also reduced by turmeric and curcumin.

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The formulation of NaF tablets using Cellulose Acetate Phthalate (CAP) as matrix material, with an intention to prepare slow release buccal tablets for the prevention of dental caries is developed. Various micrometric studies of granules and tablets (containing different concentrations of CAP are studied. Dissolution studies are also carried out in distilled water at 37 +/- 1 degree. Significant variations in granule and tablet) parameters depending upon the concentration of CAP is observed. The in-vitro drug release reveals that T80 percent values are above 90 min for formulations containing more than 30 percent CAP. The drug dissolution is diffusion controlled and follow the Higuchi equation. The fraction of the drug release is proportional to time 1/2. Preliminary clinical data will also be discussed.

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Two spectrophotometric methods for the determination of Diltiazem in Pharmaceutical preparations are described. The methods are based on the formation of coloured complex of the drug with cobalt-thiocyanate and methyl orange. The coloured species were extracted into organic solvents and measured at the wavelengths of maximum absorbance at 630 nm and 420 nm with cobalt and methyl orange respectively. Both the methods shows linearity in the range 60-600 mug/ml and 5-60 mug/ml respectively.

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A reverse phase high performance liquid chromatographic method has been developed for the simultaneous estimation of penbutolol sulfate and hydrochlorothiazide in tablets. A Chromegabond M C 18 column with a mobile phase of 50 mM Na2HPO4: acetonitrile (60:40 v/v) adjusted to pH 3.5 with orthophosphoric acid was used. The flow rate was 1 mL/min and effluent was monitored at 220 nm. Samples as low as 278 ng/ml of penbutolol sulfate and40 ng/ml of hydrochlorothiazide can be estimated. Propranolol HCI was used as internal standard, and the order of elution was hydrochlorothiazide (HTZ) : propranolol : penbutolol (PEN) (3.43 : 5.57 : 10.76 minutes,respectively).

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Diclofenac Sodium was formulated as microspheres using egg albumin by chemical cross linking and as inclusion complex with betacyclodextrin. Studies were done on entrapment efficiency,Particle size, diffusion and dissolution pattern.

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Simple, rapid and senstive spectrophotofluorometric and fluorodensitometric methods for the estimation of allyloestrenol are described. The drug on heating with sulphuric acid reagent in methanol yields a fluorescent derivative which has excitation lamda max at about 292 nm and emission lamda max at about 355 nm. It obeys Beer's law in the concentration range of 0.8 to 8 mcg/ml. Alternatively the drug is quantitated by the use of TLC densitometer (scanner). The methods are found to be accurste.

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A high performance liquid chromatographic method for the determination of nonoxynol-9 in contraceptive preparations is described using Lichosorb RP-8 column, eluate being monitored at 280 nm using phenylbutazone as internal standard.

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