Microspheres of Diclofenac sodium were prepared using carriers such as albumin, ethyl cellulose, gelatin,calcium alginate and waxes by different techniues of microencapsulation. The yield varied from 65 percent to 85.2 percent. The stability of the drug in the formulations was confirmed by IR and TLC studies. Drug associated with the microspheres was estimated and it ranged from 14.5 percent to 90 percent. Scanning electron microscopy revealed the morphology of microspheres. Size of the particles in different microspheres as determined by Optical microscopy ranged from 36.3 mum to 46.6 mum. Short term stability studies were carried out at 60 degree C, 37 degree C, Room temprature (RT) and 5 degree C and they were all foundstable except microspheres with waxes and albumin as the carriers which were unstable at 60 degree C. In-vitro release studies were carried out at different pH for a period of 8h and compared with pure drug and marketed samples. The rate of release of drug from the microspheres of gelatin and ethyl cellulose was significantly retarded.

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A simple ioscratic reverse phase method for the determination of 4-methoxy 8-pentyl-1-napthoic acid, methyl elcosanoate, acevaltrate, isovaleroxyhydroxydidrovaltrate and didrovaltrate in the rhizomes of Valeriana wallichii was developed and is described. The senstivity was found to be linear in the range of 0.2-5 ug. To the best of our knowledge this is the first HPLC report for the determination of napthoic acid derivative and methyl eicosanoate in this plant.

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From the alcoholic extract of stem bark of Mangifera indica cultiver Chausa two new triterpenic constituents, namely manghopanal and mangoleanone, have been isolated and characterized in addition to known compounds taraxerol, friedelin, C-24-epimer of cycloart-25-en-3Beta, 24,27-trioltriacetate, mangiferonic acid and phenolic component mangiferin.

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The Beta-t-alkylaminoalkoxy phenyl Furanobenzopyrones (14 compounds) were synthesised and screened for antifertility activity. Two of them, 2.9-Diphenyl-4-methyl-3 [P-(2-dimethyl amino etnoxy)phenyl]-7H furo [2.3-f] [1] benzopyran-7-one (IVe) and 2.9 diphenyl-3[P-2- dimethylaminoisopropoxy) phenyl]-7H Furo [2.3-F] [1] benzopyran-7-one (IVg) were found to possess marked antifertility activity in rats.

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A simple, precise & rapid, reversed phase high performance liquid chromatographic method was developed for the simultaneous determination of Cephalexin & Probenecid in tablets, on a Novapak C18 (4micron) column using Water:Methanol:Acetonitrile:Glacial Acetic Acid (50:20:30:1) as mobile phase. The flow rate was 1.5 ml/min. and effluent was monitored at 254nm. The minimum detection limit obtained for both the drugs was 2 mcg/ml. Nifedipine was used as an internal standard & the order of elution was Cephalexin:Nifedipine (I.S):Probenecid (4.34:6:22:8.7 min respectively. Results obtained were statistically comparable.

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Effect of chloramphenicol on the incorporation of L-phenylalanine - 14C(U) into hyoscyamine, scopolamine and total proteins was studied in flowering plants of Datura innoxia Mill. Chloramphenicol, at a concentration of 200 mg/l increased the incoroporation of the precursor into L-hyoscyamine and scopolamine. Concomitantly, a reduction in the incorporation of the same precursor into protiens was noted. An inverse correlation between the alkaloid yield and total protiens was discernible.

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Complexes of Copper (II) with N1- isonicotinyl-3-methyl-5-pyrazolone, (IMP) and N1-isonicotinoyl-3-methyl-4-hydroxbenzylidine-5-pyrazolone, (IMHP) having the formula Cu(NO3)2 IMP and CuCl2IMHP were synthesized and biological activity studied. In vitro cytotoxic studies using these drugs indicated that 100 percent cytotoxicity could be produced to Ehrilich ascites tumour cells at a concentration of 10 mu g/ml . Tissue culture studies using Chinese Hamster Ovary Cells resulted in 50 percent and 70 percent growth inhibition with 1 mug of Cu(NO3)2 IMP and CuCl2IMHP respectively.Administration of the drugs (30 mg/kg for 5 days) to Ehrilich ascites tumour bearing Swiss albino mice resulted in an increase in the life span of 80 percent with the former while, the animals treated with the latter drug remained free of tumour for 90 days.

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A rapid and simple method for the determination of cephalexin (CPN) is presented. The method is based on the catalytic hydrogen wave noticed in presence of cobalt (II) and the drug at a potential of -1.47 V vs SCE. The drug can be determined over the range of 1.97 to 9.86 mug/ml. The method has been successfully applied for the determination of other pharmaceutical formulations containing cephalosporin.

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