Solid dispersin of nifedipine in combined carriers, PVP-MCC and HPC-MCC has markedly enhanced the dissolution rate and efficiency of nifedipine. About 30-37 fold increase in the dissolution rate was observed with these dispersions. The enhanced dissolution rate was due to (i) the conversion of nifedipine into amorphous form and (ii) the enhancing effect of PVP and HPC on the solubility of nifedipine. Dissolution of nifedipine from these dispersions obeyed Hixson-Crowell's cube root dissolution rate equation.

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Oleo-gum resin Commiphora mukul and its formulations are widely used for their multifarous activities ranging from astringent, antiseptic, to cholesterol and lipid lowering activity.Colorimetric assay procedure has been reported for the estimation of sterodial contents as guggulsterone using betamethasone as a standard.Different microbial tests were also pefromed to check the microbial contamination in the Oleo-gum resin.

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Vesicles containing vincristine were prepared using different nonionic surfactants and by employing different techniques. The entrapment efficiency and the stability in terms of drug leakage of the noisomes prepared by different methods were compared. Transmembrane pH gradient (inside acidic) drug uptake process (TMpH) was proved to be most satisfactory yielding 90 drug entrapment when span 40-cholesterol (1:1) were used as vesicle forming agents. A relatively slow release pattern of the entrapped vincristine from the niosomes prepared by this method indicates an enhanced stability of the system.

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A simple, HPTLC method was developed for the simultaneous determination of furazolidone and metronidazole from their combined dosage form. The separation was carried out using a precoated HPTLC plate-Merck (Silica Gel 60 F254) and densitometric scanner was used for quantitation.

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Itaconic acids were synthesised by a modified sttoble condensation and esterified to dimethyl and diethyl itaconates. Compounds were evaluated for biological activity and some were found to possess significant anti-inflammatory and analgesic activities.

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Coumarin was converted by Glecocladium roseum NRRL 1859 into three metabolities 4-hydroxycoumarin, 7-hydroxycoumarin and 6,7- dihydroxy-coumarin-6-glucoside in 21 percent, 26 percent and 10.5 percent yield, respectively. 7-methoxycoumarin was obtained (13 percent) by transformation of coumarin by C. tropicalis. The identity of the isolated metabolites were established using mp, ms, uv and both H- and C-NMR spectral analysis.

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Synthesis of novel Beta-N.N-disubstituted aminoethoxy derivatives of benzophenones and napthophenones has been carried out from corresponding substituted benzophenones and napthophenones. Compounds 11.22 & 28 showed spermicidal activity at 1 concentration.

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The influence of ketoconazole on the pharmacokinetics and hypoglycaemic activity of tolbutamide was determined as a preclinical study in normal rabbits with adequate controls. Ketoconazole treatment (20 mg/kg, oral once daily for one week) significantly increased the terminal half-life and AUC 0 --> infinite of tolbutamide (40 mg/kg, oral) when compared to controls. The hypoglycaemic activity of tolbutamide was also enhanced and prologned significantly in ketoconazole treated rabbits. It appears that ketoconazole decreases the in vivo hepatic metabolism of tolbutamide in rabbits.

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