During screening of 12 essential oils of higher plants against two ringworm fungi Trichophyton mentagrophytes and microsporum audounil by poisoned food technique, the oils of plants viz. Cinnamomum tamala, Citrus maxima, Cymbopogon citratus, Eucalyptus citriodora, Eupatorium cannabinum, Nepeta hindostana Ocimum canum showed absolute toxicity against both the test fungi. The minimum inhibitory concentration of the oils of Cinnamomum tamala and Citrus maxima was 500 ppm against both the test fungi and these oils showed superiority in efficacy over some synthetic antifungal agents. The oils exhibited fungicidal or fungistatic nature of toxicity.

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Micropheres of Diclofenac Sodium were prepared by coacervation phase separation method. Chitosan and glutaraldehyde were used as coating material and cross-linking agent respectively. Optimum conditions for preparation, factors affecting the in-vitro release from hard gelatin capsules in phosphate buffer (pH 6.5) and mechanism of drug release are identified. The in-vivo bioavailability testing was carried out in rabbits and the results were compared with that of solution of diclofenac sodium. The data demonstrates tht controlled release forulation of diclofenac sodium can be developed using chitosan as a biopolymer. The microspheres exhibited good spherical geometry and released the drug according to the Higuchi model.

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The effect of chlorhexidine-alcohol admixture on glucose utilisation and growth suppression of Ps. aeruginosa were examined. Correlation was observed between glucose utilisation and suppression of growth rates. When growth inhibitory were investigated, the results showed effects that exceed additivity.

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Terfenadine is a selective second generation H1 reactor antagonist which is a non-sedating antihistamine. Terfenadine has been analysed by non aqueous titration,gas chromatography, HPLC and spectrophotometry. In the present communication, a new simple and senstive spectrophotometric method is reported for the determination terfenadine.

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Benzimidazoles were prepared by Mannich reaction and antibacterial rested against S. aureus, B. subtilis, S. sonnie and A. aerogenes. Antiinflammatory activity of the compound was determined by carragenin-induced rat paw oedema method using a digital plethysmometer. Indomethacin (10 mg/kg) was employed as a standard drug.

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Seven marketed antacid suspensions have been comparatively studied for their acid consuming capacity and rate of neutrailzation. It is derived that this sort of study is a good indicator for the in vitro evaluation of the idealness of an antacid preparation.

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The petroleum ether extract of the root of Aristolochia Albida (Family Aristolochiaceae) on column chromatography and subsequent elution with petroleum ether and benzene (1:4) yielded a semipure fraction which gave a melting point of 134 degree. By repeated preparative TLC impregnated with 12.5 percent AgNO3,the fraction was found to be a mixture of Beta-sitosterol campesterol and stigmasterol. This was confirmed by GC:MS.

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Eight salicylhydroxamic acids and their fifty six metal chelates with VO(II), Cu(II), Ni(II), Co(II), Fe(II), Mn(II) and ZN(II) were screened for their antifungal activities which ecxhibited that metal chelates are more active than the parent salicylhydroxamic acids, being maximum for metal chelates of Co(II) with halo-and nitro-substituted salicylhydroxamine acids.

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Iontophoresis and sonophoresis have been tried to enhance the transdermal permeation of insulin. Some of the affecting physicochemical parameter have been optimized in vitro and evaluated in vivo using albino rats.

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