Differential scanning calorimetry (DSC) was employed as a tool to investigate the physico-chemical compatability between metoprolol tartrate and a number of commonly used excipients. Metoprolol was found to be compatable with microcrystalline cellulose (Avicel PH 101®), Eudragit® and colloidal silicon dioxide (Aerosil®). Although metoprolol showed interactions with stearic acid, magnesium stearate, lactose, sodium carboxymethyl starch/sodium starch glycollate (Primojel®), Indian CRP 234and starch, one cannot conclusively state that interaction incompatabilities will occur on storage at room temperature.

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The pharmacokinetics of rifampicin (50 mg/kg i.p. daily for 6 days) was studied in control rats and those simultaneously treated with 12 mg/kg Picroliv, a standardised irridoid glycoside mixture from roots and rhyzomes of Picrorhiza kurroa. Picroliv did not modify the pharmacokinetics of rifampicin.

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Several 1-(N-arylsuphonylhydrazine carbonylmethyl)-2(1H)- quinoxalinones were prepared by condensing aryl sulphonylchloride with 2-(1H)-quinoxalinon-1'yl-acetyl hydrazine in presence of pyridine. The constitution of the products was supported by elemental analysis, IR, PMR and mass spectral study. The compounds synthesised were tested in vitro against Salmonella typhosa, Escherichia coli, Bacillus megaterium, and Stephylococcus citrus and a fungal strain, Aspergillus niger. Standard drugs were also tested under identical conditions for comparing the results.

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A sensitive ELlSA method for estimation of folic acid in multivitamin formulations has been developed. The assay relies of simple sample preparation step followed by dilution of extracted sample. The detection limit of the assay is 0.1 pg/well. Intra- and interassay variation ranged between 2.7 to 5.1%. Analytical recoveries obtained after spiking with different amount of folic acid ranged between 94 to 104%. The present assay procedure is accurate, selective and useful for direct measurement of folic acid in multivitamin formulation.

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Cisapride is a substituted piperidinyl benzamide chemicaly related to metoclopramide. Its full chemical name is (±) cis-4-amino - 5 - chloro -N [1-[3-(4- flurophenoxy) propyl] ] -3-methoxy-4-piperidinyl]-2- methoxybenzamide.[1]. The reported methods of analysis are the non-aqueous potentiometric method using Ag/AgC1 electrode[2] and the HPLC UV detection method, for the estimation from body fluids[3]. In the present communication the development of a colourimetric method based on charge transfer (CT) complex formation of cisapride with iodine and catechol is reported.

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Bioconversion of pure solasodine and the quantitative changes in the phytoconstituents of

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