Solvent deposition of Chlordiazepoxide on starch-lactose in different proportion in Granules was done using evaporation technique. The tablets prepared using solvent deposition technique and conventional wet granulation technique have been compared for content uniformity and dissolution rate. The product have been characterised using X- ray diffraction studies, scanning electron mocroscopy and differential scanning calorimetry. The results revealed that solid state crystalline transition and not the molecular micronisation, were responsible for increased dissolution rates.

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Delta-Amyrin alongwith beta- sitosterol and beta-amyrin have been isolated from the leaves of Gymnosporia montana.

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Compressed 25 mg suppositories of naproxen, suitable to tropical were formulated and evaluated for bio-availability and other pharmacokinetic parameters and the results were compared with those of suspension in rabbits. Different pharmacokinetic parameters after oral and rectal administration of naproxen were calculated using a model independent computer program "RAMKIN". The differences in pharmacokinetic parameters, c max,AUC-24h, t1/2 and MRT obtained after oral and rectal administration of naproxen were statistically insignificant (P>0.05) revealing good performance of the compressed suppositories of naproxen. Absorption was faster from suspension as can be expected. Results indicated bio-equivalence of naproxen from compressed supositories and suspension.

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Polyacrylamide microcapsules have been investigated as carriers for achieving site specific delivery of 5-Fluorouracil (5-FU). Acrylamide was cross-linked with N N' methylene-bisacrylamide using an emulsion polymerisation procedure. Spherical microcapsules with mean diameter 2.65 +/- 0.37 mu m and drug entrapment effciency of 60.33 +/- 3.68 percent were obtained. In vivo organ distribution studies in rats showed maximum drug accumulation in lungs, followed by liver and kindneys. Time course vs. drug tissue concentration profiles indicate that the deposition of the drug in the organs occured at a slow rate, showing peak drug levels at 24 hours post injection.

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"Action of Methyl Acetoacetate on 3,4-diaminobenzophenone was studied under different reaction conditions."

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The different postulated models of the NSAIDs are presented and briefly discussed.

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3-(p-Cinnamoylphenyl) sydnones (4-16) obtained by condensation of 3-(p-acetyphenyl) sydnones with aromatic aldehydes were condensed with 2-aminothiophenol to yield title compounds (17-29). These were evaluated orally for antiinflammatory and analgesic activities. Except compound 17 all were found to be inactive.

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A simple method has been developed for the determination of sulphonamides present in different sulpha drugs, using N, N-dibromo dimethyldantoin.

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