The Extended Hildebrand Solubility Parameter Approach (EHSA) is suggested to predict the solubility of drug in binary and ternary solvent blends. The solubility profile of metronidazole Dioxane-water blends shows a bell shaped curve with solubility maxima different from the calculated ideal solubility. The approach was found better for the prediction of solubility.

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The communication reports the derivation of relationships that can be directly applied to correct raw dissolution data for loss of drug and /or volume reduction during manual sampling in with replacement and without replacement studies.

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Whole plants of Fumaria indica (fam.Fumaricease) were studied for their hepatoprotective activity against carbontetrachloride, paracetamol and rifampicin-induced heptatotoxicities in albino rats. The petroleum ether extract against carbonetrachloride, total aqueous extract against paracetamol and methanolic extract against rifamiplcin-induced hepatotoxicities showed similar reductions in the elevated levels of some of the serum biochemical parameters in a manner similar that of silymarin indicating its potential as a hepatoprotective agent.

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A Simple, precise and rapid reversed phase HPLC method was developed for the simultaneous determination of atenolol and amoldipine from pharmaceutical formulations. The recovery and statistical validations were also carried out to find its applicability in routine quality control.

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The essential oil of the leaves of Uvaria narum wall (Annonaceae) was obtained by steam distillation. Out of the 80 components detected in the oil, 8 were identified by GC-MS analysis. The oil showed good antibacterial and antheimintic activity.

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Two simple spectrophotometric methods are described for the determination of albendazole mebendazole or fenbendazole based on oxidation of the drug with a known excess of N-bromosuccinimide (NBS) and estimating the unreacted NBS with metol-sulphanilmide (lmax 520nm; Method A) or celestine blue (lmax 540 nm; Method B).

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A new colorimetric method for the determination of thiamine hydrochloride is developed. It is based on the formation of coloured ion-pair complex between thiamine hydrochloride and alizarin brilliant violet R in the aqueous phase at pH 4.5 extractable into chloroform which obeyes Beer’s law in the range of 2-16 mcg/ml.

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Two sensitive spectrophotometric methods for the determination of Amlodipine besylate based on the formation of coloured complexes of the drug with regents such as Erichrome Black- T at pH 3.0 and indigo caramine at pH 2.8 are described for bulk samples and pharmaceutical preparations. The ion-pair complexes formed are quantitatively extracted into chloroform under the experimental conditions.

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Solid dispersions of hydroxpropyl b- cyclodextrin (HPB), a highly water soluble derivative of b- cyclodextrin and piroxicam (PRX) were prepared by kneading, co-evoporation and freeze-drying. X-ray diffraction, differential scanning calorimetry, IR-spectral studies and thin layer chromatography were used to characterise the solid dispersions and also to study the possibility of complexation of the drug with HPB. A marked difference in characteristics of dispersions was observed due to their methods of preparation. The dissolution of PRX from the solid dispersion was studied by the dispersed powder technique and also as per USP 1990 which was found to have improved considerably over that of the pure drug alone. Coevaporated and freeze dried dispersions caused significant reduction in irritation to stomach mucosa of rats upon oral administration.

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Micropellets of Pentazocine hydrochloride were fabricated by the emulsion – solvent – evaporation method using different combinations of ethylcellulose and Eudragit RL 100. The polymer combinations, drug load, and pH of the dissolution medium were found to extert important effects on the drug release profiles. Release kinetics also showed a heterogeneous pattern.

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Moschosma polystachya (Lamiaceae), an oil rich (0.6%) taxa, was found to contain methyl eugenol (39.3%), methyl lisoeugenol (8.4%), limonene (7.4%), 1,8-cineole (5.3%), β-elemene (5.1%), β-caryophyliene (4.8%), β-selinene (3.8%), citronellal (3.5%), geranyl acetate (2.9%), α-humuiene (2.4%), isobornyl acetate (1.8%) and δ-cadinene (1.6%) as major components.

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From the petroleum ether fraction of the aerial parts of Swertia alata three bioactive xanthones, viz., 3-methoxy-1,7,8-trihydroxyxanthone, 1,8-dihydroxy-3,5-dimethoxyxanthone and 1,8-dihydroxy-3,7-dimethoxyxanthones have been isolated and identified by different chemical and spectral methods.

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A simple spectrophotometric method has been developed for the estimation of rutin from pharmaceutical dosage forms using the chromogenic agent, 3-methyl benzothiazolin-2-one hydrazone (MBTH). The coloured complex exhibits maximum absorption at 500 nm and obeys Beer’s law in the concentration range of 10-50 mcg/ml of rutin.

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A simple and sensitive spectrophotometric method for the determination of lansoprazol is described. The method involves the reaction of lansoprazol with p-dimethylamino benzaldebyde in acidic medium. The method described is precise, accurate and reproducible and is extended to the analysis of capsule.

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A simple and rapid spectrophotometric method has been described for the assay of Loratidine in bulk drug and dosage forms. The method is based upon the reaction of loratidine with potassium lodide in the presence of hydrochloric acid to yield a chromogen having absorption at 370 nm.

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