A prodrug of Ciprofloxacin was synthesized by reacting the free base with aqueous formaldehyde solution in a 1:1 mixture of methylene chloride and methanol. The colourless, crystalline Nhydroxymethyl derivative, m.p. 238-242 degree C showed enhanced solubility and a three fold increase in the dissolution rate over parent drug. The degradation kinetics, pH-rate profile and antimicrobial activity of the prodrug were also determined.

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In Ayurveda, various preparations are used for liver disorders. Abhrak bhasma (100 puts), Praval bhasma agniputi), Mandur bhasma, Loha bhasma and Arogyavardhini Rasa No.1 were screened for antihepatotoxic activity in albino rats treasted with CCl4, using the liver to body weight ratio,pentobarbitone sleeping time and serum levels of SGPT, SGOT, alkaline phosphatase and bilirubin. Abhrakbhasma and Arogyavardhini were found to have good hepatoprotective activity.

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Transdermal Films of Flurbiprofen and Diclofenac Sodium were prepared using HPMC and Beta Cyclodextrin. The films were evaluated for physicochemical characteristics, release pattern, Pharmacodynamic activity and Bioavailability.

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Three commercial creams of clotrimazole (CLTZ) were tested for in vitro release and anti fungal activity. Release and anti fungal activity showed an inverse relation, indicating that these parameters are governed by two independent mechanisms. Release was related to particle size according to Noye's Whitney hypothesis, but it was inversely related to Electrokinetic potential (EKP) indicating that electrical double layer is a barrier retarding the release. A linear relationship between anti fungal activity and EKP reveals that, since EKP is a measure of spreadability and dispersibility of creams, via these factors it is influencing the anti fungal activity. As the release data fitted well in to Higuchi's square root law and Hixson-Crowell equation, it is inferred that both matrix type and diffusion controlled mechanisms are governing release.

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Several fluorine containing 3' -phenylspiro [3H- indole-3, 2' -thiazolidine]-2, 4' (1H)-dions were synthesised. Reaction of 2-mercaptopropionic acid/mercaptoacetic acid with fluorinated 3-aryyliminoindole-2-ones,prepared in situ from indole-2, 3-diones (isatins) and fluorinated anilines, afforded the title compounds. Alkylation of spiro compounds under Phase- Transfer-Catalysis yielded exclusively N-alkylated indole. The spiro compounds were converted into corresponding thiones. Representative compounds were screened for antifungal,antibacterial and insecticidal activities. Enhanced antifungal, antibacterial and insecticidal activities were recorded when sulphur was added to the representative compounds.

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Neproxen 500 mg (2 x 250 mg tablets) alone and in combination with dapsone 100 mg tablet was administered to seven healthy human volunteers in a sequential design. Plasma concentrations were determined during a 48 hr. period following drug (s) administration. The plasma levels and pharmacokinetic parameters such as C max, t max, AUC, t1/2, V,CL and MRT of naproxen were not affected significantly (p>0.05) in presence of dapsone. In vitro protein binding interaction between naproxen and dapsone was studied by equilibrium dialysis method using bovine serum albumin. No significant variation in protien of naproxen was observed in presence of different concentrations of dapsone.

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The ascorbic acid oxidizes electrochemically at the surface of the dropping mercury electrode. Oxalic acid which is used as extracting agent for ascorbic acid does not influence the anodic wave and does not react with it. Defined anodic waves are obtained if the potential range of polarogram is kept in the range 0-300m V. pH 4.0 was found to be the most satisfactory for determination of ascorbic acid. The ascorbic acid in synthetic and various medicinal samples was determined by internal addition method.

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An ocular drug delivery device of Ciprofloxacin was designed with the aim to overcome the drawbacks of conventional eye medications. The drug release pattern and stability of these devices were studied.

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The anti-inflammatory activity of liposomal indomethacin was compared with that of free indomethacin in female albino rats. A statistically significant difference was found between the anti-inflammatory effect of free and liposomal indomethacin in reducing carrageenan-induced oedema in rats.

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Two spectrophometric methods are described for the determinations of Phenothiazine tranquillizers based on the formation of chloroform extractable complexes exhibiting absorption maxima at 520 nm with Amaranth and Fast red-E in acidic medium. The ion-pair methods has been applied to the determination of promethazine HCL, chlorpromazine HCL, thioridazine HCL, trifluoperazine HCL, triflupromazine HCL, methdilazine HCL and fluphenazine HCL as raw materials and from their pharmaceutical formulations.

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Two senstive methods for the determination of Nortriptyline HCI based on the formation of coloured complexes of the drug with regents such as Light Green FCF at pH 5.0 and Orange- ll at pH 2.0 are described in bulk samples and in pharmaceutical preparations. The ion-pair complexes formed are quantitatively extracted into chloroform under the experimental conditions.

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Epoxy resins and hydrochloride salts of aryloxypropanolamines of bisphenol derivatives were synthesised and characterised by elemental, IR, 1H NMR spectral data. All the compounds were screened for their antibacterial, antifungal and hypotensive activities.

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