Indian Journal of Pharmaceutical Sciences Indian Journal of Pharmaceutical Sciences(0250-474X),, is the official scientific publication of the Indian Pharmaceutical Association. It started in 1939 as the Indian Journal of Pharmacy. The journal is published Bimonthly. Indian Journal of Pharmaceutical Sciences Volume 86, Issue 2 An Overview of Highly Efficient Prodrug Strategies In Design Development Bioactive Pathway and Recent Therapeutic Applications G. Chandravadivelu* and D. D. Magharla NanospongeAn Emerging Nanomaterial in Recent Advancement of Novel Drug Delivery An Overview and Future Perspectives S. Nandi* and Poulomi Biswas Review on the Pharmacognostical Phytochemical and Pharmacological aspects of emTabernaemontana coronariaem Kirubavathi Sekar*, R. Vijaya Bharathi, S. R. Ajai Franco and R. Radha Sodium Glucose Cotransporter2 Inhibitors An Overview from Evolution to Clinical Implications Ramya Ravi, V. Balasubramaniam, S. Dhingra, K. Murti and S. Ponnusankar* Perspective on Solid Lipid Nanoparticles as Drug Delivery System for Infectious Diseases Prachitee Ayare*, Apurva Bakre and Rajashree Hirlkear Calycosin Inhibits Pancreatic Cancer Cell Proliferation Migration and Invasion by Repressing Circ0000285 Ruibing Ma, Xiaoping Yu and Kun Cheng* Houttuyn Berberine Promotes Apoptosis of Nasopharyngeal Carcinoma Cells and Inhibits Proliferation Migration and Invasion by Regulating the circSMARCA5microRNA346 pathway Dongbao Yang, Xiaodong Wen, Jing Xiao, Hong Qin, Jie Hou, Yujie Li, Xiaojun Liang and Fuyu Qiao* Pharmacognostic and Physicochemical Studies of emAerva sanguinolentaem L Blume K. Manda, A. B. Kasetti, R. J. R. Yendluri , Risy Namratha Jamullamudi, Saritha Karnati, B. P. Arakareddy and Netala Silvia* Study on the Mechanism of Kukoamine A Attenuating Interleukin1 Beta Induced Chondrocyte Damage by Downregulating microRNA302b3p Yuntao Li, Zhaoli Wang*, Qi Zhang, Lin Shen, Yang Zhang and Yue Guo emIn Vitroem Anti Angiogenetic Activity of Traditional Plants emSaraca asocaem emGlycyrrhizia glabraem and emCurcuma longaem Beneficial for Endometriosis Treatment Reshmi Nair, Shehna Sharaf, Lakshmi Sreedharan, Kizhiyedath Polachira Suja and K. K. Sabu* SerumDerived Exosomes MicroRNA923 and MicroRNA523 Expression to Regulate Autophagy in Esophageal Squamous Cell Carcinoma H. Chen, Rongyu Xu, Rongqi He*, S. Chen, J. Fu, Hongbo Chen and Xiangkun Du Total Flavonoids of emEucommia ulmoidesem Oliver Protects Cardiomyocytes against LipopolysaccharideInduced Injury by Regulating microRNA494 Expression C. Sun, Xueli Ren, Feini Wu, Wei Chen, J. Wang and Lili Deng* Effect of Liraglutide Regulating Phosphoinositide 3 KinaseProtein Kinase BART Pathway on Myocardial Injury in Rats with Acute Myocardial Infarction Yu Lu and Houxiang Qin* 5 AlphaReductase Inhibitory Potential of emSolanum nigrumem Effective for Management of Alopecia A. Chakraborty*, Arka Bhattacharjee, M. Chakraborty and G. Mukhopadhyay Evaluation of the Optimum Oral Dosage of Bromelain after Impacted Third Molar Surgery Shriya Ginde*, Sonal Shah, Sonal Kale, P. Lunkad and Y. Patil Effect of Cyclophilin A on Biological Behavior of Placental Trophoblast Cells in Severe Preeclampsia by Regulating HIF1 Alpha Signaling Pathway Han Wang, Juan Du and Xiangbing Jiang* Investigation of Expression and Correlation of Exogenous Interleukin10 and GATA Binding Protein3 in Nasal Mucosa of Allergic Rhinitis Rats Jing Tong*, Kaidiliya Kaisaier, Airifate Ainiwaer and Aini Aihaiti Effect of Angiotensin IIMediated Janus KinaseSignal Transducers and Activators of Transcription Pathways on Thoracic Aortic Smooth Muscle Cells Ru Zhang, Zhong Lu and Zhongya Yan* Acute Toxicity of Epigallocatechin Gallate and CPhycocyanin in Zebrafish emDanio rerioem Behavioral and Histopathological Studies Ajungla Jamir, Sentiyanger Longkumer and P. P. Punj* emIn Vitroem Studies on the Effects of Water Miscible Organic CoSolvents on Select Drug Metabolizing Enzyme Activities K. R. Iyer*, S. H. Kamble, T. S. Shah, Pranali Patil, T. S. Tomar, Shraddha Betgiri, R. S. Tanna, S. Sankaran and Kavita Raikuvar Isolation and Identification of Bacteriocin Producing Microbial Strains from Rhizosphere Soil Vahid, Sarita Mallik* and Muskan Tyagi Polysaccharides from Semen Plantaginis Regulates the CircularTTC3microRNA27a3p Axis to Alleviate Myocardial Cell HypoxiaReoxygenation Injury Binwang Lv, Yiqun Teng, Xu Zhang and Yixue Yu* Platycodin D Impairs the Oncogenic Phenotypes of Esophageal Squamous Cell Carcinoma Cells by Elevating microRNA4319 Shuo Zhang, Yinghua Ma and Xiao Geng* Rutin Prevents Spinal Cord Neuroinflammation emviaem Downregulating p38 MitogenActivated Protein Kinase Signaling Pathway Tiejun Shi, Peixin Wang, Tao Wang, Fanxuan Kong, Yikun Sun, Hao Huang and Nan Li* Identification and Toxicity Profiling of Degradation Products of Haloperidol by Using Tandem Mass Spectrometry and emIn Silicoem Studies R. Chodankar* and A. Mahajan Effect and Mechanism of microRNA in Exocrine Secreted by Hepatitis B Infected Hepatocytes on Activation of Hepatic Stellate Cells and Hepatic Fibrosis Yang Gao, Shengning Zhang, Xibing Zhang, Shiming Feng and Li Li* Investigating the Impact of emAstragalusem Polysaccharide on Angiogenesis in Human AdiposeDerived Stem Cells Wen Ke, Zhang Jun, Shi Jingjun, Chen Xu and Huang Jinlong* Formulation Development and emIn Vitroem Evaluation of Diclofenac Sodium Injection for Pain Management A. Padiyar* and R. K. Maheshwari Mechanism of Linagliptin on Stromal CellDerived Factor 1 and Vascular Endothelial Growth Factor Protein after Molar Pulp Revascularization in Rats Ye Zhou, Yongjing Liu, and Xiaowen Lu* BoxBehnken Design Assisted UltraPerformance Liquid ChromatographyPhotodiode Array Detection Method Development Validation and Quantification of Lunasin Peptide from Nutraceutical Formulation K. Gullapalli, A. Karthika and K. Nagappan* Effects of Vitamin D Deficiency on Metabolic Diseases Induced by HighFat Diet in Young Male Rats and Its Possible Mechanism Fengxia Wang, Zhendan Xu, Xin Li, Zhanglin Wang, Jihong Wang and Yi Zhang* Exploring Cosolvency in Analytical Method Development and Validation of Poorly Aqueous Soluble Candesartan Cilexetil in Bulk and Dosage Forms P. S. Yadav, A. A. Hajare*, R. S. Dhole and S. V. Dharangutikar Pharmacological interactions among Paediatrics in Tertiary Care Hospital Shaima Shereen* and A. H. Syed Effect of microRNA5155p on Biological Behavior of Colorectal Cancer Cells through Phosphoinositide 3Kinase Protein Kinase B Signaling Pathway Wenyuan Zhang, Chongling Zhang, Bo Liu, Meiling Wang, Yongjing Yang and Shixin Liu* Quality by Design Based Stability Indicating Quantitative Reverse Phase High Performance Liquid Chromatography Method Development and Validation for Bilastine in Tablet Dosage Form D. J. Pandya*, C. N. Patel and Khushbu Patel Formulation Optimization and Evaluation of Sustained Release Tablet of Tramadol Hydrochloride Juti Rani Devi*, Arundhuti Kashyap and B. Das Improvement of Solubility and Dissolution of Telmisartan by Solid Dispersion Technique An investigation on Effects of Carrier using Multiple Comparison Analysis Manami Dhibar*, C. Santanu and P. Ayan Analysis of the Effect of Nux Vomica on Three Models of Chondrocyte Apoptosis Liang Guo and Fengjiao Yu* Role of Neuronal Nrdp1USP8Hypoxia Inducible Factor1 Alpha Signal Axis in Hypoxic Injury after Cerebral Ischemia Leifang Yang, Bin Ren* and Yangjun Han MCP1 Regulates Fractalkine Secretion through p38MAPK Signaling Pathway in Rats with Advanced Bone Cancer Pain Y. Zhang, H. Qian, Xiaofei Cheng, Ting Zhou, C. Zhong, F. Tian and Q. Sun* Recombinant Human Growth Hormone Promotes Burn Wound Repair by Regulating Vascular Endothelial Growth Factor and Micro Vessel Density Xiannan Liang* and Xinlong Chen Folic Acid Combined with LCarnitine Alleviates Vascular Endothelial Injury in Preeclampsia Rats by Regulating Oxidative Stress Injury and Inflammatory Factor Expression Zifeng Song, Y. Jiang*, Chunyu Zhang, Hongdan Liu and P. Hu Effect of Ginsenoside Rd on the Biological Characteristics of Lung Adenocarcinoma H1299 Cell Line Wei Ding, Xudong Qin, Lingjie Zhou and Zhixiang Ming*