A facile synthesis, in vitro antiinflammatory and antioxidant activity of novel benzimidazolylpyrano[2,3-d][1,3]thiazolocarbonitriles
1Department of Pharmaceutical Chemistry, Vaageswari College of Pharmacy, India 2Department of Pharmacy, University College of Technology, Osmania University, India
R Anisetti Department of Pharmacy, University College of Technology, Osmania University, Hyderabad-500 007 India E-mail: [email protected]
The synthesis benzimidazolylpyrano[2,3-d][1,3]thiazolocarbonitriles (5a-j) were achieved by cyclocondensation of arylidene amino-benzo[d]imidazole-2-thiols (3a-j) with mercaptoacetic acid followed by cyclization with 2-(phenylmethylene)malononitrile. Further more, the present study aimed at the evaluation of in vitro antiinflammatory activity and antioxidant activity of synthetic compounds. All tested compounds showed appreciable activity against the standard drugs.