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Abstract

A rapid and precise colorimetric method for estimation of 5- fluorouracil in bulk drug and dosage forms.

Author(s): SK Banerjee, A Sumathi
Pharmacy Dept., Faculty of Technology and Engineering, M.S. University of Baroda, Kalabhavan, Baroda 390001

Correspondence Address:
S K Banerjee Pharmacy Dept., Faculty of Technology and Engineering, M.S. University of Baroda, Kalabhavan, Baroda 390001

The proposed colorimetric method for estimation of 5-Fluorouracil (5-FU) is based on the reaction between the drug and copper acetate in 3:2 chloroform : methanol mixture in presence of 0.5 percent diethylamine (DEA). The yellowish green coloured complex shows a lamda max at 350 nm and calibration curve was obtained within the range 0.4-11.0 mug/ml. The method is statistically validated and results compared favourably with those obtained by the reported method.