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Abstract

A Reversed Phase High Performance Liquid Chromatographic Method For Estimation Of Nevirapine In Tablets

Author(s): K Venugopal, Y Srinivasa Rao, K. E. V Nagoji, G Haritha, J. V. L. N Sheshagiri Rao

A reversed phase HPLC method is described for the determination of nevirapine in tablet dosage forms. Chromatography was carried out on an ODS column using a mixture of methanol and water (50:50 v/v) as the mobile phase at a flow rate of 0.9 ml/min. Cefixime was used as an internal standard and the detection was done at 230 nm. The retention time of the drug was 6.69 min. The method produced linear responses in the concentration range of 0.5 to 60 μg/ml of nevirapine. The method was found to be applicable for analysis of the drug in tablets. The results of the analysis were validated statistically.