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Abstract

Adsorption studies of phenformin hydrochloride on some clays and its application in formulating sustained release dosage forms.

Author(s): RK Maheshwari, SN Sharma, NK Jain
Dept. of Pharmaceutical Sciences, Doctor H. S. Gour Vishwavidyalaya, Sagar (M.P.) 470 003,

The adsorption of phenforim hydrochloride from aqueous solution on bentonite, montmorillonite, kieselgurh, china clay, fullers earth and Kaolin N.F. was studied. Bentonite and montmorillonite were found to possess adequqte adsorption capacities and hence their complexes with drug were subjected to drug content analysis and dissolution rate studies. Based on these studies, sustained release formulations were made and subjected to in-vivo evaluation using fall in blood sugar level of alloxan induced diabetic rabbits. Duration of action was found to be 10 to 11 hours.